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Turning Back The Clock On Aging: Telomir Pharmaceuticals Confirms Telomir-1 Reverses Age And Increased Longevity In Breakthrough Pre-Clinical Study

Benzinga

By Meg Flippin, Benzinga Turning back the clock on aging is the holy grail for the longevity industry, but is something that has proven elusive. That may be changing, thanks to companies like Telomir Pharmaceuticals Inc. (NASDAQ: TELO). The pre-clinical-stage company positioning itself as an emerging leader in age-reversal science is making inroads with Telomir-1, a compound designed to effectively turn back the biological clock and support longevity. Results from a preclinical trial confirmed the efficacy of the compound, reports Telomir. Using advanced in vivo microfluidic technology, in collaboration with Nagi Biosciences SA, the study demonstrated what Telomir said is significant age-reversal effects in aging model organisms treated with Telomir-1. These effects include an extended healthy lifespan, improved mobility and a measurable reversal of age-related decline. “The results we’re seeing with Telomir-1 mark an important step forward in our journey to potentially reverse aging in humans,” said Erez Aminov, Chairman and CEO of Telomir Pharmaceuticals in a press release announcing the trial results. “This study confirms that Telomir-1 can reverse biological aging, extending life while preserving health. We are very excited about the potential applications of Telomir-1 as we progress toward human clinical trials” Anti-Aging In A Compound Telomir-1 is focused on telomere regeneration which involves repairing telomeres or the DNA structures that protect the ends of our chromosomes, similar to caps on shoelaces. Numerous studies have shown fixing them can extend a person’s biological age and even turn back the clock on certain diseases. Telomir Pharmaceuticals says Telomir-1 is a novel small molecule to lengthen the DNA’s protective telomere caps in order to potentially reverse age-related conditions. The novel molecule, which Telomir is testing with mice and dogs with an eye toward human clinical trials, binds to critical metals that wear down telomeres. By limiting the availability of metals and interrupting the enzyme function, Telomir-1 seeks to restore cellular metal homeostasis and reverse a person's or animal’s biological age. The non-toxic oral therapy provides what the company says is a safe and effective alternative to existing treatments with minimal side effects. Telomir says Telomir-1 has the potential to impact patient care by offering new hope for managing and reversing age-related diseases and improving the quality of life for aging individuals. The Study Details The preclinical study, conducted in collaboration with Nagi Bioscience, utilized a sophisticated in vivo microfluidic-based assay to assess the effects of Telomir-1 on the nematode Caenorhabditis elegans, a well-established model for aging studies, reports Telomir. The microfluidic platform allowed precise, automated tracking of lifespan, healthspan and age-related mobility decline in real-time, enabling the research team to accurately measure the effects of Telomir-1 on these critical metrics. Two forms of Telomir-1 were administered in two concentrations. The study found that Telomir-1 significantly enhanced lifespan and healthspan parameters in aged microorganism populations. Some of the key findings include enhanced mobility in older organisms, reduced biological aging and increased lifespan. Subjects treated with Telomir-1 showed improved mobility, particularly in later stages of life compared to untreated controls. Telomir also said the study demonstrated “a measurable” reversal of biological age markers which the company said makes it a promising candidate for longevity treatments. What’s more, the company said Telomir-1 was associated with a statistically significant increase in lifespan among treated populations, further supporting Telomir-1’s role in promoting longevity. "At Nagi Bioscience, we are thrilled to contribute to this groundbreaking study through our innovative microfluidic technology, which allows precise and automated monitoring of aging and healthspan metrics in real-time,” said Dr. Laurent Mouchiroud, Chief Scientific Officer at Nagi Bioscience. “These results highlight Telomir-1’s remarkable potential to improve longevity and health, showcasing the power of cutting-edge tools in advancing age-reversal science." Expanding Telomir-1’s Reach Telomir sees many market opportunities for Telomir-1. There’s the longevity and anti-senescence therapy market, which is valued at $27.11 billion and is projected to reach $44.92 billion by 2031, growing at a CAGR of 6.8%. Then there’s Alzheimer's. Nearly seven million Americans suffer from this disease that attacks memory and cognitive functions. By 2050 that’s forecast to reach close to 13 million. And let's not forget cancer, another area Telomir-1 could prove effective in fighting. The global oncology market size is projected to reach $521.60 billion by 2033, growing at a CAGR of 8.9% from now until then. An additional area where Telomir-1 may help is in the treatment of progeria, a rare genetic disorder that causes accelerated aging in children. Telomir is intensifying its focus on the potential use of Telomir-1 to treat progeria and has engaged with the Progeria Foundation to investigate the effects of Telomir-1 on human progeria cell lines. This study will directly assess Telomir-1’s ability to counteract accelerated aging at the cellular level, offering critical insights into its therapeutic potential for progeria patients. Telomir also planned an in vivo study utilizing a progeria Caenorhabditis elegans model. This advanced microfluidic-based assay will evaluate Telomir-1’s impact on longevity, healthspan and biological aging in an organismal context. Telomir said these two studies represent a comprehensive approach to understanding Telomir-1’s effects on progeria, targeting both cellular and whole-organism models of the disease. On the canine front, Telomir is in talks with the North Carolina State College of Veterinary Medicine to establish a large-scale study on elderly dogs with osteoarthritis, further exploring Telomir-1’s potential to improve joint health and mobility. Turning back the clock on aging is the quest of many companies. Telomir believes it's getting closer to the successful formula. With the company all in with Telomir-1, stay tuned for more news on the trial front from this early-stage anti-aging innovator. Featured photo by JD Mason on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 22, 2024 09:00 AM Eastern Standard Time

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Bitcoin Price Hits All-Time High – How You Can Trade The Cryptocurrency’s Growth Trajectory

Benzinga

By Kyle Anthony, Benzinga In a relatively short time frame, society’s sentiment towards cryptocurrencies seems to be shifting from skeptical to almost celebratory as the versatility of digital currencies has become more apparent, which is reflected in the fact that the price for Bitcoin hit an all-time high recently after the U.S. elections. Furthermore, the recent securitization of Bitcoin and Ethereum has helped legitimize and expand the value proposition of these currencies, turning them into regulated investable assets that individuals and institutions can trade or allocate to within their portfolios. While this rising popularity has gathered the interest of many individuals, it has also made them aware of the price volatility present within the asset class, leading some to wonder about the underlying dynamics of cryptocurrencies and if it is right for them. But others say there is no need to worry– for example, with Plus500’s Crypto offerings, CFD Crypto assets are available to trade with a leverage of 1:2 while Future Crypto assets are available for U.S. traders. Factors That Influence Cryptocurrency Prices Though Bitcoin, Ethereum and other cryptocurrencies are digitally native, supply and demand factors still influence their price. Given that Bitcoin's underlying protocol/coding limits its supply to 21 million coins, fluctuations in demand can lead to price volatility. Mining new Bitcoin is an energy-intensive process that requires the collaboration of various stakeholders within the blockchain ecosystem. Additionally, investor interest, adoption rates and macroeconomic conditions also affect demand. A seminal factor influencing Bitcoin’s price is ‘ Bitcoin Halving,’ which occurs every four years. The last one occurred on April 14 th, 2024. In simple terms, Bitcoin Halving reduces the rate at which new coins are created. Thus, it is self-induced scarcity written into Bitcoin’s code. The rationale for these quadrennial halving events is to reduce the supply of Bitcoin entering circulation, thus allowing existing coins to keep their value (i.e., avoid inflation). Similarly, supply and demand dynamics also influence Ethereum's pricing; however, the cryptocurrency’s underlying protocols also influence its value. In 2021, Ethereum developers enacted Ethereum Improvement Proposal 1559 (EIP1559), which overhauled Ethereum’s transaction fee mechanism in a way that impacts users, miners and holders of Ethereum. One of the results stemming from this change relates to how users would transact on Ethereum. More specifically, the change required that users destroy an algorithmically determined amount of the cryptocurrency, thus limiting its oversupply on the network and the possibility of inflation. Finally, Bitcoin and Ethereum's mass adoption and securitization are also influential pricing factors. After rejecting Bitcoin for almost a decade, the U.S. Securities and Exchange Commission approved spot Bitcoin ETFs in January this year, which resulted in several ETF makers launching these solutions. The approval of Ethereum ETFs soon followed. Outside the U.S., some markets, such as Hong Kong, are also launching cryptocurrency ETFs, as there is growing investor demand for these asset types. The securitization of these cryptocurrencies and the usage of these instruments by retail and institutional investors is a growing factor influencing their price. Overall, it’s important for traders to exercise caution and adapt their strategies as new information and market trends emerge, striking a balance between risk and reward. For example, with Plus500 you can learn the basics of risk management with their trading academy tools. How To Trade Cryptocurrencies The price volatility present in cryptocurrencies, specifically Bitcoin and Ethereum, is indicative of an active market. As with most asset classes, be it stocks, bonds, commodities or other such instruments, there will be periods of upswings and drawdowns. This cyclicality in price creates opportunities for individuals to enter at a reasonable price point and benefit from potential appreciation. Alternatively, they can take a short position if they believe the current valuation is too high and a correction will occur. Individuals who want to gain exposure to cryptocurrencies can achieve this in multiple ways. As mentioned previously, Bitcoin and Ethereum ETFs are now available to the broad market. These ETFs allow individuals to have turnkey access to the respective cryptocurrencies in a unitized solution. ETFs are possibly the most accessible avenue for individuals looking to invest or trade cryptocurrencies. Cryptocurrency futures are contracts between two investors who speculate on a cryptocurrency's future price, giving them exposure to cryptocurrencies without purchasing them. Crypto futures resemble standard futures contracts because they allow traders to speculate on the price trajectory of an underlying asset. For traders or speculators, using cryptocurrency futures enables them to capitalize on the dynamic shifts that occur with these currencies. Finally, individuals can buy the specific cryptocurrency they desire through a cryptocurrency trading service or exchange. Doing so would provide them with direct ownership of their chosen cryptocurrency. Why Consider Cryptocurrencies Now? Against the backdrop of an uncertain macroeconomic and geopolitical landscape, the decentralized nature of Bitcoin, Ethereum and other cryptocurrencies has risen in appeal as investors seek to diversify their portfolios. Simply put, cryptocurrencies broaden the risk and return spectrum available to investors. In other words, for investors willing to take more risk, the cryptocurrency asset class may have the potential to deliver higher total returns in the form of tradable instruments widely available on exchanges. How To Trade Cryptocurrencies With Plus500 Plus500 (OTC: PLSQF) is a multi-asset fintech group operating trading platforms globally. Established in 2008, the firm has grown its importance as a player in the financial trading sector, being listed on the London Stock Exchange under the ticker symbol PLUS and included in the FTSE 250 Index. Given the group’s global operations, it is regulated by several entities, including the UK's Financial Conduct Authority (FCA), the Australian Securities and Investments Commission (ASIC), the Israel Securities Authority (ISA) and others in Europe and Asia-Pacific jurisdictions. Regarding service offerings, Plus500 is expanding and currently offers three platforms: Plus500 Contract For Differences (CFD) with more than 2800 CFD instruments, Plus500 Invest with more than 2700 shares (available in certain countries) and Plus500 Futures, which is a futures platform available in the U.S. only. As a trading platform, Plus500 is designed to be straightforward and accessible for beginners while offering advanced features for experienced traders. Beginner traders should use the demo account and all the resources in the Trading Academy. Traders can start with as little as $100, and Plus500 Futures (U.S.) offers a deposit bonus of up to $200. For traders interested in cryptocurrency CFDs, Plus500 can provide up to 1:2 leverage on such transactions. Plus 500 also provides educational resources to upskill one’s trading ability and ongoing 24/7 professional support as needed. Ready to begin your cryptocurrency trading journey? Click here to check out the Plus500 platform! *82% of retail CFD accounts lose money. Trading in futures and options carries substantial risk of loss is not suitable for every investor. The valuation of futures and options contracts may fluctuate rapidly and unpredictably, and, as a result, clients may lose more than their original investments. Featured photo by Traxer on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

November 22, 2024 08:45 AM Eastern Standard Time

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Siyata Reports Record Third Quarter Revenue Amid Strong US Demand

Siyata Mobile Inc.

By Meg Flippin, Benzinga The land mobile radio market is getting an overhaul thanks to push-to-talk over cellular (PTToC) technology. After all, PTToC gives first responders, miners, dock workers, security professionals and a whole host of other professionals access to instant communications, wider nationwide coverage and greater cost efficiencies. Not to mention these advanced PTToC systems can easily integrate with legacy technology and are future-proofed for when 5G completely dominates. Those benefits haven’t been lost on Siyata Mobile Inc. (NASDAQ: SYTA), a Vancouver, British Columbia, global vendor of PTToC devices and cellular signal booster systems. The company reports it had a strong third quarter with record revenue growth thanks to outsized demand for its rugged devices. What’s more, the company said it is still on track to achieve profitability in the coming quarters. “We continue to see the rapid adoption of our disruptive solutions and, as the displacement of land mobile radio by push-to-talk-over-cellular continues to progress, this should drive meaningful growth,” said CEO Marc Seelenfreund during the company’s earnings call for the quarter. “We stand by our previously stated goal of strong revenue growth with the goal of profitability in the coming quarters.” Shift Underway It’s no wonder Siyata saw triple-digit revenue growth in the third quarter. The market seems to be undergoing a shift away from Land Mobile Radio (LMR) systems and toward PTToC technology. The industry is forecast to grow at a CAGR of 11% from now until 2030, reaching $68.94 billion. Siyata Mobile’s portfolio of in-vehicle and rugged devices enable first responders and enterprise workers to instantly communicate over a nationwide cellular network of choice. Meanwhile, its portfolio of enterprise grade and consumer cellular booster systems enables first responders and enterprise workers to amplify cellular signals in remote areas, inside buildings where signals are weak due to their structures, and within vehicles. Those devices – the SD7 in particular – drove growth for Siyata in the third quarter. The SD7 is a rugged handset that operates with a SIM card on public cellular networks, giving users nationwide coverage. Siyata Mobile says its radios deliver crystal-clear audio quality and since the SD7 is rugged and water resistant, it can work in most environments. For the three months ending in Sept. 30, 2024, Siyata Mobile reported record revenue of $5.9 million, up 218% year-over-year. The company attributed the revenue growth to “booming demand” for its SD7 handsets and accessories. Demand was particularly strong in the U.S. market, which represented 81% of revenue during the quarter. “This performance underscores the significant momentum we are building, especially in the U.S. market, where sales have increased by 55% year-to-date,” says Seelenfreund. “More broadly, demand for our SD7 handsets is increasing across a diversity of vertical markets and use cases. Adoption of our disruptive, ruggedized handsets is accelerating to replace more traditional land mobile radio (LMR).” Dealmaking On Display The third quarter was a busy three-month period for Siyata, in which it inked two deals. First, there was a $2.5 million order which it received for its PTT handsets and Real Time View devices from an existing customer, an international emergency medical services organization. Siyata plans to deliver the order in the first quarter of 2025. Seelenfreund said the expansion of its deal with this first responder organization is a testament to the positive impact its devices are having on customers and the relationships Siyata is cultivating. “Our devices are being proven as rugged, reliable and effective for enhancing communications when deployed by lifesaving EMS customers, thereby leading to follow-on orders,” said Seelenfreund. Then there is Siyata’s deal with T-Mobile US (NASDAQ: TMUS). Siyata’s SD7 Ultra series 5G mission-critical push-to-talk (MCPTT) cellular radio handsets will be available on T-Mobile's 5G network, currently the nation's largest. Siyata’s SD7 devices will be available through T-Mobile's Direct Connect platform. Users will also have access to applications Siyata says are designed to improve response times and ensure that emergency services can effectively address critical situations. “We believe that we have a very exciting 5G product portfolio planned to launch in 2025 which will position us as the leading PTT handset provider on a global level,” says Seelenfreund. “We announced recently that T-Mobile is the first wireless carrier that will be launching part of the portfolio and will be releasing details of the innovative devices over the coming months. We are optimistic that more wireless carriers will follow suit.” Siyata is having a moment driven by demand for its rugged devices. With the third quarter in the bag and new deals about to go live, Siyata may be worth keeping an eye on. Featured photo by Fred Moon on Unsplash Siyata Mobile Inc. is a B2B global vendor of next-generation Push-To-Talk over Cellular devices, cellular booster systems, and video monitoring solutions. Its portfolio of in-vehicle and rugged devices enables first responders and enterprise workers to instantly communicate, over a nationwide cellular network of choice, to increase situational awareness and save lives.Its portfolio of enterprise-grade and consumer cellular booster systems enables first responders and enterprise workers to amplify cellular signals in remote areas, inside structural buildings where signals are weak, and within vehicles for the maximum cellular signal strength possible.For its video monitoring system, Siyata integrates software that we license with off-the-shelf hardware providing our customers with an integrated advanced camera system for management and visual monitoring of their fleet vehicles. This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. Words such as "expects," "anticipates," "intends," "plans," "believes," "seeks," "estimates," and similar expressions or variations of such words are intended to identify forward-looking statements. Because such statements deal with future events and are based on Siyata's current expectations, they are subject to various risks and uncertainties, and actual results, performance, or achievements of Siyata could differ materially from those described in or implied by the statements in this press release. The forward-looking statements contained or implied in this press release are subject to other risks and uncertainties, including those discussed under the heading "Risk Factors" in Siyata's filings with the Securities and Exchange Commission ("SEC") and in subsequent filings with the SEC. Except as otherwise required by law, Siyata undertakes no obligation to publicly release any revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. References and links to websites and social media have been provided as a convenience, and the information contained on such websites or social media is not incorporated by reference into this press release. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Brett Maas SYTA@haydenir.com

November 22, 2024 08:20 AM Eastern Standard Time

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Why Cutoshi The Viral Sensation Adopting Satoshi Nakamoto's Teachings Is Trending Globally Alongside BTC And DeFi

Cutoshi

As Cutoshi trends on X for the second time this month, Bitcoin also trends as it hits fresh all-time highs of $98,300. Why Is Cutoshi Trending? On November 20th, Cutoshi’s native token $CUTO hit the number one trending spot on X, with BTC and DeFi. As the coin makes it to the top spot of X for the second time this month. The team has many inspirations and that’s the work and ethics of Bitcoin’s pseudonymous creator, Satoshi Nakamoto. Satoshi stood for privacy, decentralization and financial autonomy and that’s exactly what Cutoshi is giving to people. So What Will DeFi Look Like With Cutoshi? Cutoshi’s plan is to leverage the mass appeal of memes to bring new people into the fold of crypto investing, trading, DeFi and the Cutoshi ecosystem. The next step is to make DeFi fun and easy to use. Currently, over 2000 community members are participating in token farming, which will result in airdrops, a big part of DeFi over the last few years. After that comes the Cutoshi DEX, currently in development. This will be easy to use, especially due to its cross-chain capabilities. This is important since bridging across blockchains can be daunting and risky, even for those competent in DeFi. The DEX will also offer peer-to-peer trading for true anonymity, another important part of the ethos of Nakamoto. Other features will include the possibility to stake and provide liquidity, essential features for decentralized exchanges, which rely on automated market makers and liquidity pools rather than CEXs order book styles. What Good Is All Of That If People Don’t Understand How To Get Involved? That is the question that prompted the Cutoshi team to start creating an education platform. Keeping with the meme style of Cutoshi, this will be fun and easy to learn with, to encourage people to get involved whatever their experience or skill levels. Early community members are in line to be eligible for a limited edition set of NFTs that will be beautiful but also functional, providing DeFi-based utility within the ecosystem. What’s Next For The Project? In the short term, Cutoshi has its sights set on $1 million in funds raised in the presale. With approximately $65k to go before this milestone is hit. Cutoshi will continue to raise funds and build the DeFi ecosystem while the price increases throughout the presale. They will continue their marketing efforts as the project and community build hype. The project is then set to launch on a DEX and later on a tier 1 CEX. If previous meme coins that have DeFi functionalities (e.g. SHIB) are anything to go by, this could be a presale that brings massive gains. For more information on the Cutoshi (CUTO) Presale: https://cutoshi.com/ Join and become a community member: https://twitter.com/CutoshiToken https://t.me/cutoshi Welcome to Cutoshi, the revolutionary meme coin, DeFi hub and educational platform inspired by the Lucky Cat and Satoshi Nakamoto’s teachings. Traditionally, people put the Lucky Cat in their homes and businesses to maximize its lucky powers and bring them good fortune and wealth. Now Cutoshi the Lucky Cat is on the blockchain bringing luck, prosperity, and wealth to your digital assets. Cutoshi is creating a path to financial freedom, for those who choose to honor the power of the Lucky Cat. Supporting the principles of freedom, privacy, anonymity, and monetary empowerment for the masses. Cutoshi aims to bring the benefits of blockchain to everyone. The regulatory environment surrounding cryptocurrencies is evolving and varies across jurisdictions. It is your responsibility to ensure compliance with applicable laws and regulations in your country or region before engaging with Custoshi. Contact Details Cutoshi hello@cutoshi.com Company Website https://cutoshi.com/

November 22, 2024 05:57 AM Eastern Standard Time

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XLRE ETF – A Strategic Approach to Real Estate Investment

Select Sector SPDR

The Select Sector SPDR Real Estate Sector ETF ( XLRE ), introduced in 2015, remains a relevant option in the real estate investment landscape. Designed for investors keen on exploring Real Estate Investment Trusts (REITs) and real estate management and development markets, XLRE offers a focused strategy that includes key sectors like Industrial, Data Center, and Telecommunications. Portfolio and Holdings* The fund currently maintains a portfolio of 31 stocks dedicating a substantial share—more than 60%—to its top ten holdings. This allocation strategy demonstrates XLRE's approach to maintaining a focused portfolio of real estate investments. Prominent Holdings Include: ProLogis (9.50%) American Tower A (9.06%) Equinix (7.83%) Welltower (7.09%) Digital Realty Trust (4.98%) Public Storage (4.71%) Simon Property A (4.71%) Realty Income (4.70%) Crown Castle (4.24%) CBRE (3.58%) Low Expense Ratio One of XLRE’s standout features is its expense ratio, which is currently at 0.09%**. This cost-effective structure provides an option for investors seeking exposure to the real estate sector without incurring high fees. Transparency and Reporting XLRE prides itself on transparency, offering daily reporting on portfolio holdings and allocations. This practice allows investors to have a clear and up-to-date understanding of where their funds are invested. S&P 500 Component Companies By including only S&P 500 component companies, XLRE ensures that its portfolio is primarily comprised of large-cap names in the real estate sector. This alignment offers investors a predictable and reliable pathway for real estate investment. Investor Considerations Investors considering the XLRE ETF as part of their portfolio can benefit from its strategic approach to the real estate sector. By focusing on a concentrated collection of high-quality real estate companies, XLRE provides an opportunity to gain targeted exposure. About XLRE The Select Sector SPDR Real Estate Sector ETF (XLRE) serves as a gateway to real estate investment opportunities, simplifying access to REITs and Real Estate Management & Development markets. With over $7 billion in assets under management, XLRE has a dedicated focus on sectors such as Industrial, Data Center, and Telecommunications. DISCLAIMER: This is a work of research and should not be taken as investment or financial advice. Therefore, Select Sector SPDRs or the publisher is not liable for any decision made based on the publication. About the Company: Select Sector SPDR ETFs offer flexibility and customization opportunities. Many investors have similar outlooks, but no two are exactly alike. Select Sector SPDR ETFs let investors select the sectors that best meet their investment goals. *Holdings, Weightings & Assets as of 10/31/24 subject to change **Ordinary brokerage fees apply DISCLOSURES The S&P 500 Index is an unmanaged index of 500 common stocks that is generally considered representative of the U.S. stock market. The index is heavily weighted toward stocks with large market capitalizations and represents approximately two-thirds of the total market value of all domestic common stocks. The S&P 500 Index figures do not reflect any fees, expenses or taxes. An investor should consider investment objectives, risks, fees and expenses before investing. One may not invest directly in an index. Transparent ETFs provide daily disclosure of portfolio holdings and weightings All ETFs are subject to risk, including loss of principal. Sector ETF products are also subject to sector risk and nondiversification risk, which generally will result in greater price fluctuations than the overall market. Diversification does not eliminate risk. An investor should consider investment objectives, risks, charges and expenses carefully before investing. To obtain a prospectus, which contains this and other information, call 1-866-SECTOR-ETF (732-8673) or visit www.sectorspdrs.com. Read the prospectus carefully before investing. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is distributor for the Select Sector SPDR Trust. Media Contact: Company: Select Sector SPDRs Contact: Dan Dolan* Address: 1290 Broadway, Suite 1000, Denver, CO 80203 Country: United States Email: dan.dolan@sectorspdrs.com Website: https://www.sectorspdrs.com/ *Dan Dolan is a Registered Representative of ALPS Portfolio Solutions Distributor, Inc. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is the distributor for the Select Sector SPDR Trust. SEL007974 EXP 1/31/25 Contact Details Dan Dolan +1 203-935-8103 dan.dolan@sectorspdrs.com Company Website https://www.sectorspdrs.com/

November 22, 2024 05:00 AM Eastern Standard Time

New Alvarez & Marsal Fall 2024 Consumer Sentiment Report Highlighting the Impact of Ongoing Consumer Skepticism on Holiday Plans and Winter Spending

Alvarez & Marsal Consumer and Retail Group

· Since the sharp pullback observed during last year's holiday season, consumers have maintained conservative spending habits. · Consumers are demonstrating greater loyalty to stores over brands, challenging the conventional notion of brand loyalty · Shoppers are expected to pull back their spending across all major holiday spending categories this year · Although in-store shopping remains the primary channel, consumers are increasingly gravitating towards online platforms for their holiday purchases Global professional services firm Alvarez & Marsal’s Consumer and Retail Group (A&M CRG) released its latest consumer report, Consumer Sentiment Survey Fall 2024, which analyzes how shifting economic conditions have shaped consumer spending patterns over the past year and explores anticipated spending behaviors for the next six months. This seventh edition of the bi-annual Consumer Sentiment Report draws from a survey of 2,100+ U.S. adults, demographically representative across gender, age, ethnicity, region and income. The report examines evolving consumer behaviors in response to personal finances and economic conditions. It provides insights into shopping priorities across categories, economic conditions, holiday plans, and other key factors influencing purchase decisions for the upcoming fall season, alongside other relevant consumer trends. These insights help retailers optimize inventory, marketing, and pricing while improving their market position. “In today's cost-conscious market, consumers are doing more research and spending less. Retailers must deliver clear value to win their business,” stated Chad Lusk, Managing Director at Alvarez & Marsal’s Consumer and Retail Group. “Consumers are playing it safe with their wallets these days - the fizzle in their optimism since last spring tells us they tightened their belts after the holidays last year and aren't in a hurry to loosen up again. “ The study found that: Consumer outlook for holiday spending is weaker compared to Fall 2023, as consumers anticipate spending less Inflation, interest rates and the job market are the top three macro- economic trends impacting consumer spending decisions Higher income consumers ($100K+) have relatively consistent spending plans, while lower income brackets are planning to spend 13% less this year Higher income households are prioritizing saving, with plans to increase savings by 4% in households making $100K or more. In contrast, lower income households are planning to save 4% less compared to previous periods As consumers look for savvy ways to decrease holiday spending, lower income consumers (<$100K) will purchase less expensive gifts this year while higher income consumers will find other ways to cut back such as waiting for items to go on sale “This holiday season, retailers should be mindful of consumers' cautious approach to spending and adjust their strategies to better align with holiday shopping behaviors and budgets,“ Lusk advised. “To appeal to value-focused consumers, retailers can optimize their omnichannel experience and pricing structure to match evolving shopper priorities and spending plans.” To download a pdf of Consumer Sentiment Survey Fall 2024, please visit: https://alvarezandmarsal-crg.com/insight/consumer-sentiment-survey-fall-2024/ The Alvarez and Marsal Consumer and Retail Group (CRG) is a management consulting firm that tackles the most complex challenges and advances its clients, people, and communities toward their maximum potential. CRG combines the best of A&M’s broader firm's bias toward action and practicality with deep consumer and retail industry experience. CRG partners with businesses across a wide range of categories including Food & Beverage, Beauty & Personal Care, Grocery, Mass Merchandise, and Apparel & Footwear to drive significant performance improvement. Contact Details David Schneidman dschneidman@alvarezandmarsal.com Company Website https://www.alvarezandmarsal.com/industries/retail/retail

November 21, 2024 03:15 PM Eastern Standard Time

COMCAST CELEBRATES 2024 RISE GRANT RECIPIENTS

Comcast Colorado

Yesterday, Comcast brought together more than 100 Comcast RISE recipients, partners, local officials, Comcast leaders and more from across Southern Colorado for Comcast RISE Day: an evening of education, collaboration, networking and recognition. The Comcast RISE program awarded a total of $500,000 in grants along with technology makeovers, marketing assistance, coaching sessions and education resources to 100 small businesses in Southern Colorado this year. Southern Colorado is one of five communities in the nation chosen for the 2024 program. “I’m confident that with the marketing assistance and technology makeover, we can more effectively share the type of experience we offer, increase our occupancy, and ensure more happy guests have a RAD Colorado experience,” said Erin Welch, RISE Grantee and Owner of RAD Hostel in Colorado Springs. Comcast RISE Day was a way to provide ongoing investment and help ensure the long-term success of these small businesses, which are the bedrock of economic growth in their communities. “Thanks to Comcast RISE, I now have an opportunity for a fresh start, and resources to grow my business.” Said Rique Lucero, RISE grantee and Owner of ColorSplashPaintball in Pueblo, CO. “Small businesses are the backbone of our communities, and Comcast is dedicated to the success and empowerment of these local businesses in Southern Colorado.” said J.D. Keller, Regional Senior Vice President, Comcast Mountain West Region. “Our mission for Comcast RISE is to ensure these businesses can prosper, thrive, and create a sustainable impact across Colorado.” Comcast RISE was created in November 2020 to help small businesses hardest hit by COVID-19 by providing the grants and services needed to survive and recover. The program since evolved from helping businesses survive the pandemic, to helping businesses and their communities achieve stronger economic growth. Held at the United States Olympic and Paralympic Museum in Colorado Springs, the event featured networking, a marketplace offering connections to local resources through Colorado Springs Chamber and EDC, the BBB of Southern Colorado, The Pueblo Economic Development Corp., and the Pikes Peak Small Business Development Center, as well as Comcast Business. Robert Thompson, Vice President, Comcast Business in the Mountain West Region, emceed the evening, and we were honored to hear from Jonathan Liebert, CEO/Executive Director, Better Business Bureau of Southern Colorado, who discussed how AI can be a power-up for small businesses. More information is available at https://www.comcastrise.com/. About Comcast RISE: Comcast RISE is part of Project UP, the company’s $1 billion commitment to advance digital equity through programs and community partnerships that connect people to the Internet, advance economic mobility and open doors for the next generation of innovators, entrepreneurs, storytellers and creators. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on broadband, aggregation, and streaming with over 56 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Comcast Leslie Oliver +1 303-810-6326 leslie_oliver@comcast.com Company Website https://colorado.comcast.com/

November 21, 2024 11:33 AM Mountain Standard Time

California Transit Training Consortium Celebrates 20th Anniversary with New Brand Identity at California Transit Association Conference 2024

California Transit Consortium

The California Transit Training Consortium (CTTC) will celebrate its 20th anniversary at the 59th Annual California Transit Association Conference and Expo with the unveiling of a refreshed brand identity. This milestone marks two decades of leadership in transit workforce development and highlights CTTC’s ongoing commitment to empowering California’s public transit professionals through innovative training solutions. Founded in 2004 by James Ditch, who recognized the need for California’s transit agencies to collaborate on workforce training, CTTC has since become an essential force in the public transit industry. Ditch’s vision of unified efforts to strengthen workforce development remains central to the organization’s mission today. This 20-year milestone reaffirms CTTC’s brand promise, “Mastering Transit Excellence with Innovative Learning.” Legacy of Impact and a Future of Innovation Over the past two decades, CTTC has trained thousands of transit professionals with the skills needed to navigate the evolving landscape of public transit, ensuring safety, efficiency, and reliability across California’s systems. The refreshed visual identity honors CTTC’s storied past while looking ahead, positioning the organization to meet the demands of a rapidly changing transit workforce. “Our new brand honors the legacy that James Ditch built 20 years ago,” said Rashidi Barnes, CTTC marketing committee chair. “It reflects our core values of collaboration, education, and innovation—values that have been at the heart of our success. This rebranding not only refreshes our look but also reaffirms our purpose: to elevate California’s transit workforce through exceptional, forward-thinking training programs.” The 20th-anniversary celebration and rebranding will be highlighted at the California Transit Association Conference at the San Jose McEnery Convention Center. Attendees will have the opportunity to connect with Maggie Pears, CTTC’s executive director, to learn more about the organization’s future direction. Exclusive branded giveaways will also be available to commemorate the event which can be found at Booth #329 on the expo floor. Symbolism and Significance of the New Brand The refreshed brand features a modernized logo that emphasizes collaboration, with the two “T’s” symbolizing mentorship—one person guiding and training another. The updated color palette retains the signature Brand Blue, now paired with vibrant accents to symbolize the energy, innovation, and forward momentum defining CTTC’s future. “As we celebrate 20 years of CTTC’s leadership in transit training,” said Dr. Yachun Chow, manager of zero-emission truck and bus programs at the California Air Resources Board (CARB), “CARB recognizes the crucial role the organization has played in advancing safety, efficiency, and sustainability in California’s transit systems. As we accelerate the shift to zero-emission fleets, CTTC’s new forward-thinking brand highlights its commitment to preparing the workforce for the challenges and opportunities ahead. Ensuring our transit operators are equipped to support electric and clean energy technologies is vital to meeting California’s climate goals.” About CTTC Established in 2004 by James Ditch, the California Transit Training Consortium (CTTC) is a 501(c)(3) nonprofit organization dedicated to advancing public transit workforce development. Through strategic partnerships with transit agencies, educational institutions, and industry experts, CTTC delivers cost-effective, state-of-the-art training programs. For the past 20 years, CTTC has empowered thousands of professionals with the skills necessary to ensure the safety, reliability, and success of public transit across California. For more information, visit cttc.com. Contact Details California Transit Training Consortium Maggie Pears Executive Director +1 310-694-3969 maggie.pears@cttc.com Company Website https://www.cttc.com

November 21, 2024 12:18 PM Eastern Standard Time

Native Made Market Returns to Rochester NY for Its Third Year on Small Business Saturday

Native Made Market

The Native Made Market is back for its third annual event on Small Business Saturday, November 30th, from 11:00 a.m. to 5:00 p.m., at 60 Brown’s Race, Rochester, NY 14614. This year, the celebration extends into the evening with a Community Dinner and Haudenosaunee Social Dance, hosted by Native American Community Services, from 5:30 p.m. to 8:30 p.m. The Native Made Market offers an immersive and intimate experience to shop Native made goods, connect with Indigenous artists, activists, and allies, and engage with organizations advancing the mission of increasing Indigenous visibility. This vibrant market celebrates Indigenous talent, cultures, and entrepreneurship, bringing together creators from across Turtle Island. Represented Nations include all Six Nations of the Haudenosaunee Confederacy, Cherokee, Piscataway, Odawa, Navajo, Sac and Fox, and beyond! This year’s participants include: ● Dawn Doctor ● Taylor Bonaparte ● Mary Homer ● Jerome Waterman Jr. ● Ella Jamieson ● Allan Jamieson ● Beth Anderson ● Sharon Trudeau ● Ayanna Proctor ● Awendea Kabance ● Darelyn Spruce ● Rachel Schindler ● Heather Hill ● Dohbid Pierce ● Mary Elliott ● Felicia Oliver ● Jennifer Dalimonte ● Isaac Dalimonte ● Evan Dalimonte ● Janet Dalimonte ● Angelina Hilton Participating organizations: ● Indigenous Peoples Day Committee ● Our Voices Project ● Indigenous Health Coalition, an initiative of Common Ground Health ● Rochester Museum and Science Center ● Native American Community Services ● Cugini di ROC Attendees can shop a variety of goods, from art prints and jewelry to dreamcatchers, textiles, and more, while learning about the Nations and stories that inspire each craft. The market also highlights organizations and allied sponsors dedicated to building a more inclusive future. Guests will have the opportunity to engage with community organizations, savor small samples of Indigenous foods, connect with members of Nations from across Turtle Island, and win door prizes generously donated by local businesses. Additionally, attendees can listen to stories shared by the original inhabitants of this land. To enhance accessibility, the Native Made Market will feature ASL interpretation and be live-streamed on the event Facebook page for those unable to attend in person. The Community Dinner and Haudenosaunee Social Dance following the market is free and open to the public, inviting all to come together for an evening of food, fun, Haudenosaunee social dances, and cultural exchange. Special thanks to our sponsors: Native American Community Services, RocGrowth, Envision Productions, Rochester Area Community Foundation, Genesee Land Trust, Our Voices Project, Wegmans, Visit Rochester, Rochester Museum and Science Center, Partners and Napier, Rochester Democratic Socialists of America, Mindful Matters, Greenspark Solar, Geva Theatre, MagnusApollo Design, Syracuse Cultural Workers, Common Ground Health, Cugini di ROC, Tapas 177, Aporia, Blue Heron Hills Golf Club, New City Café and Roasters, Great Lakes Gaming, Chick’n Out, Grace & Disgrace, Project Lean Nation, Ballroom at Carey Lake, Diamond Dan Publications, and Razor Pitch. For more information about the Native Made Market, please contact: Angelina Hilton at nativemadehq@gmail.com or 585-524-7408 Visit: linktr.ee/nativemadehq Facebook Event Page: https://www.facebook.com/events/768840598504853 Make A Donation: https://square.link/u/LKluwnN0 For questions about the Community Dinner and Social Dance, please contact: Pete Hill at 716-574-8981 or phill@nacswny.org Join us on November 30th to celebrate and support Native creatives, entrepreneurs, and allied organizations. Together, we are uplifting Indigenous voices in the Rochester NY area and beyond. ### About Angelina Hilton and Native Made Angelina Hilton is an enrolled member of the Sac and Fox Nation of Missouri in Kansas and Nebraska and a descendant of the Iowa Tribe of Kansas and Nebraska, Buffalo Clan. She is the founder of Native Made with a mission dedicated to increasing Indigenous visibility. Through services in marketing and collaboration—including graphic design, web design, search engine optimization, event planning, and more— Native Made amplifies Indigenous voices and stories. Angelina’s passion extends to community service, where she volunteers with White Corn Project, serves on the Indigenous Health Coalition, an initiative of Common Ground Health, and contributes to the Indigenous Peoples Day Committee in Rochester, NY and the Native American & Indigenous Business Council at Target. Angelina holds a Bachelor of Science in Advertising from the Art Institute of California – San Diego. She enjoys photography, writing, painting, singing, dancing, traveling, spending time in nature and with her family. Contact Details Native Made Market Angelina Hilton +1 585-524-7408 nativemadehq@gmail.com Company Website https://nativemadehq.com/

November 21, 2024 12:00 PM Eastern Standard Time

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