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Poolbeg Pharma's new VP of Clinical Operations Laura Maher aims to help progress development assets

Poolbeg Pharma PLC

Poolbeg Pharma PLC's newly appointed Vice President of Clinical Operations Laura Maher joined Proactive's Stephen Gunnion to discuss her role at the company. Maher detailed her responsibilities at Poolbeg, emphasising her leadership in developing and managing clinical programs. She highlighted the importance of collaborations, both internally and with external service providers, to ensure the acquisition of quality data. Maher's significant achievements at Amryt include her pivotal role in the development and approval of Filsuvez, a treatment for Epidermolysis Bullosa (EB). She oversaw the largest-ever EB trial, leading to EMA approval in June 2022, marking it as the world’s first approved treatment for EB. Despite initial FDA rejection, her perseverance led to eventual FDA approval in December 2023. Her extensive background in clinical research and operations, beginning with a research master's degree and experience in various roles across academia and small pharmaceutical companies, informs her approach at Poolbeg. Maher expressed her enthusiasm for working in a dynamic environment like Poolbeg, particularly excited about their cancer immunotherapy and cytokine release syndrome projects. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

February 08, 2024 06:27 AM Eastern Standard Time

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Startup Reduces Sugar In Natural Beverages Without Spoiling The Taste; Juice, Dairy Industries Could Be Ripe For BlueTree Technologies

OurCrowd

by Jeremy Ruden More than half of the global population – 51%, or over 4 billion people – will be obese by 2035, according to a 2023 report from the World Obesity Atlas. One of the major causes of obesity is sugar. While candy and carbonated drinks might be on many people’s radars as a primary source of sugar, natural beverages such as orange juice are also packed with it. With these health concerns in mind, scientists at startup BlueTree Technologies created proprietary technology that removes up to 50 percent of the sugar from juice and other natural beverages. BlueTree’s innovative method selectively removes a specific sugar molecule, preserving the beverages’ natural taste and health benefits. The company is now raising a funding round through OurCrowd, the global equity investment platform. “Our technology targets the disaccharides in the juice without harming the other ingredients,” says Yossi Sefi, BlueTree’s Chief Technical Officer. “It is capable of locating the exact kind of sugar in orange juice, for example, and removing it without harming the pulp, the vitamin C, the amino acids, or any other important ingredients.” In tests, half of those surveyed reported they preferred the flavor of orange juice with less sugar – while noticing no difference in the aroma and texture from the original. Successful Pilot The company, which was nurtured at the Fresh Start FoodTech incubator in northern Israel established by OurCrowd with Tnuva, Tempo and Finistere Ventures, has successfully adapted its technology for commercial applications. “We developed a turnkey platform that can be easily integrated into any manufacturing line,” says Michael Gordon, BlueTree’s CEO, who was formerly a senior director at Coca-Cola before joining the company. Gordon oversaw BlueTree’s first major deployment at a plant belonging to Priniv, one of the top three natural juice manufacturers in Israel. “It took us no more than two months to fully integrate our system and we did it without interfering with the plant’s overall operations,” Gordon says. BlueTree built all the equipment and the machinery for the Priniv installation in-house. The facility can now produce some 10,000 liters of orange juice daily, with up to 50% less sugar. BlueTree is poised for full-scale commercial production, with patents secured in the EU and Brazil, while awaiting approval from the Israeli Ministry of Health and the U.S. Food and Drug Administration. International beverage manufacturers and distributors, working to produce healthier products and avoid warning labels or progressive taxes on sugary drinks, are also showing a great deal of interest in BlueTree’s platform. The company signed an agreement with a leading international manufacturer, which it hopes will result in revenues of at least $6 million a year. It is also in advanced negotiations with other global producers in Italy and Spain and major juice manufacturers in Brazil and Thailand. One Platform The dairy industry is another target for BlueTree’s technology. Working together with a major local food manufacturer, the company produced a prototype that reduced the sugar in skimmed milk by some 75%. Commercialization plans are underway. The company also began an R&D project for beer with an international beverage manufacturer. The agreement forecasts the production of more than 200 million liters of reduced-sugar beer a year. “We can make the world better by reducing the sugar from all of nature’s liquids for all consumers,” Gordon says. “Our versatile tech could help curb the obesity crisis by cutting two teaspoons of sugar from children’s daily diet.” For more information about investing in BlueTree via OurCrowd, click HERE. Featured photo courtesy of BlueTree Technologies. OurCrowd was started in 2013, driven by the idea that the business of building startups grows bigger and better when the global ‘crowd’ gains access to VC-level investment opportunities.Today, OurCrowd is a global venture and alternative investing platform that empowers institutions and individuals to invest and engage in emerging companies. OurCrowd vets and selects companies, invests its capital, and provides its global network with unparalleled access to co-invest and contribute connections, talent and deal flow. OurCrowd builds value for its portfolio companies throughout their lifecycles, providing mentorship, recruiting industry advisors, navigating follow-on rounds and creating growth opportunities through its network of multinational partnerships. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Lisa Graston lisa.graston@ourcrowd.com Company Website http://www.ourcrowd.com

February 07, 2024 08:15 AM Eastern Standard Time

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News Release

Kadimastem Receives Patent for Its Cell Selection and Enrichment Technology Used to Develop Its IsletRx Treatment for Diabetes in India

Kadimastem

Kadimastem Ltd. (TASE: KDST), a clinical stage cell therapy company, developing and manufacturing "off-the-shelf" allogeneic cell products using its platform technology to develop treatments for different neurodegenerative diseases and a potential cure for diabetes, has been granted a patent from the Indian Patent and Trademark Office for its cell therapy technology. The cell sorting patent will be protected until November 2036 for the company's innovative cell selection and enrichment technology. This patent covers the production of IsletRx, the company's product for the treatment and potential cure for diabetes. The company's technology is unique with its ability to select and enrich only the highest functioning and purest islet cells from the population of differentiated islet-like cells which enables the maximum therapeutic effect. According to the Indian Ministry of Home Affairs, CNN and the pharmaletter India is a fastest growing economy of the global G20 with massive investments in web infrastructure and growing pharma and biotech sectors. As such biotech companies are increasingly securing their IP in India to ensure maximal potential revenues in the Indian subcontinent[1]. The approval of this patent in India is particularly important, especially in light of our collaboration project with iTolerance, a US company in the diabetes field and funded by the BIRD Foundation. The project combines Kadimastem’s and iTolerance’ s technologies to develop and commercialize a breakthrough regenerative technology to cure diabetes without the need for life-threatening chronic immuno-suppression. The project received a US $1Million grant from the BIRD Foundation for this project. Out of a total budget of US $2 Million In addition, according to statista in 2021, India was ranked second in the world with about 74.2 million diabetic adults in the 20 to 79 years old age group. The number of diabetic individuals was projected to increase to over 124 million in 2045[2]. In financial year 2021, the market size of diabetes and pre-diabetes care market in India was valued at about 17 billion U.S. dollars. It is forecasted to reach about 34 billion dollars in 2026 and 59 billion dollars in 2031[3]. Asaf Shiloni, company CEO: “Kadimastem highly believes that the company’s treatment can improve the quality of lives for hundreds of thousands of those dealing with the daily struggles of insulin dependent diabetes (IDD) by presenting a potential cure for IDD with our unique patented solution with IsletRx cells.” In May 2021, the selection technology covered by this patent was described in a peer-reviewed journal article [4] in Frontiers in Endocrinology. About Kadimastem Kadimastem is a clinical stage cell therapy company, developing and manufacturing "off-the-shelf", allogeneic, proprietary cell products based on its technology platform for the expansion and differentiation of Human Embryonic Stem Cells (hESCs) into functional cells. AstroRx®, the company's lead product, is an astrocyte cell therapy in clinical development for the treatment for ALS and in pre-clinical studies for other neurodegenerative indications. IsletRx is the company's treatment for diabetes. IsletRx is comprised of functional, insulin and glucagon producing and releasing pancreatic islet cells, intended to treat and potentially cure patients with insulin-dependent diabetes. Kadimastem was founded by Professor Michel Revel, CSO of the company and Professor Emeritus of Molecular Genetics at the Weizmann Institute of Science. Professor Revel received the Israel Prize for the invention and development of Rebif®, a multiple sclerosis blockbuster drug sold worldwide. Kadimastem is traded on the Tel Aviv Stock Exchange (TASE: KDST). About IsletRx The IsletRx product is a clinical-grade collection of pancreatic islet cells. Preclinical studies have shown that the cells are able to detect the sugar levels in the body and to produce, and secrete, on demand, the required amounts of insulin and glucagon, just like a healthy pancreas and enables the insulin dependent patient to avoid an abnormal drop in sugar level (hypoglycemia). In addition, the method of production and selection of the cells enables their implantation in various types of smaller size devices, suitable for maximum comfort for people living with diabetes. Forward Looking Statement This document may include forward-looking information as defined in the Securities Law, 5728 – 1968. Forward-looking information is uncertain and mostly is not under the Company's control and the realization or non-realization of forward-looking information will be affected, among other things, by the risk factors characterizing the Company's activity, as well as developments in the general environment and external factors affecting the Company's activity. The Company's results and achievements in the future may differ materially from any presented herein and the Company makes no undertaking to update or revise such projection or estimate and does not undertake to update this document. This document does not constitute a proposal to purchase the Company's securities or an invitation to receive such offers. Investment in securities in general and in the Company in particular bears risks. One should consider that past performance does not necessarily indicate performance in the future. Social Media: LinkedIn, Twitter, Facebook [1] Press Information Bureau (pib.gov.in); Indian economy regains its swagger as China stumbles | CNN Business; India's booming bioeconomy poised for growth (thepharmaletter.com) [2] https://www.statista.com/statistics/1360381/india-number-of-adults-with-diabetes/ [3] https://www.statista.com/statistics/1359258/india-diabetes-and-pre-diabetes-care-market-size/ [4] https://www.frontiersin.org / articles/10.3389/fendo.2021.635405/full Contact Details Kadimastem Asaf Shiloni CEO s.bazak@kadimastem.com Company Website https://www.kadimastem.com/

February 07, 2024 07:23 AM Eastern Standard Time

Primer Selected for the 2024 GSV Cup 50

Spark Metro PR

Primer has been named to the 2024 GSV Cup 50 out of 1,000 nominations of pre-seed and seed-stage companies. The GSV Cup, presented by Google Cloud and GSV Ventures, and supported by HolonIQ, recognizes the world's most innovative digital learning and workforce skills startups. The GSV Cup 50 will be featured at the 15th Annual ASU+GSV Summit, the preeminent global gathering for “Pre-K to Gray” education leaders, in San Diego, CA. The GSV Cup 50 highlights the most promising startups that support learners across the Pre-K to Gray spectrum, distributed across early childhood education, K-12, higher education, workforce learning, and adult consumer learning. All nominees were evaluated against GSV’s “Five P’s” framework: People, Product, Potential, Predictability, and Purpose. "Being chosen for the GSV Cup 50 is a great honor, highlighting our alignment with GSV's values and our commitment to innovation in digital learning,” said Mark Naufel, Founder of Primer. “Being part of this elite group starts a new chapter for Primer, as we continue to revolutionize the idea of a lifelong adaptive learning experience powered by an AI personal companion." “This year’s GSV Cup was both incredibly competitive and incredibly inspiring,” said Deborah Quazzo, Managing Partner of GSV Ventures and Co-founder of the ASU+GSV Summit. “The GSV Cup 50 are undoubtedly the stars of tomorrow. With almost 80% of the companies focused on leveraging AI, they’ve got both eyes on the future of education – not just what we can see now, but what we can build beyond view. We’re so excited to see the transformative effects of these companies over the next five, ten, even fifteen years.” The 2024 GSV Cup 50 companies are poised to make a global impact, with 34% headquartered outside of the United States and representation from 15 unique countries. This year’s GSV Cup 50 also represent a variety of diverse perspectives and experiences, with 66% of the companies led by female or BIPOC founder(s). The GSV Cup 50 join a prestigious group of past Cup startups, including Ello, Ethena, LingoAce, Prenda, Stride, TransfrVR, and TeachFX. See Primer and all of the companies selected to the GSV Cup 50 at https://www.asugsvsummit.com/gsv-cup. About Primer Primer is an AI personal companion poised to revolutionize the digital learning landscape, with the market expected to reach heights of $370 billion by 2026. Leveraging a patent-pending, generative AI system, Primer offers tailored, engaging experiences that enhance both learning and daily life. Beyond traditional education, Primer learns and grows with each user, continuously evolving to meet their personal needs. It’s this seamless ability to customize learning for everyone, from inquisitive schoolchildren to professionals advancing their careers, that underscores Primer’s dedication to ensuring no one navigates through life without a worldclass advocate. About ASU+GSV Summit Now celebrating its 15th year, the ASU+GSV Summit has become the world's most important and impactful gathering of leaders across "Pre-K to Gray" education and workforce learning. Hosted in San Diego, the annual event attracts over 7,000 in-person and 10,000 virtual registrants. Past GSV keynote speakers and honorees have included Presidents George Bush, Barack Obama and Vicente Fox Quesada, Former Secretaries of Education Arne Duncan and John King, Surgeon General Vivek Murthy, Gina Raimondo, Reed Hastings, John Legend, Condoleezza Rice, Justice Sandra Day O'Connor, Priscilla Chan, Laurene Powell Jobs, and more. ### For Media Relations contact: Mark Naufel,, info@primer.net Contact Details Primer Mark Naufel +1 302-597-6768 info@primer.net Company Website https://primer.net/

February 07, 2024 12:10 AM Eastern Standard Time

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Eat To Think: The Power of Nutrient-Dense Foods for Enhanced Cognitive Function!

YourUpdateTV

No one wants to slip into their later years with a failing memory or inability to think clearly and make decisions. Recently Peter Castleman, Author of “Eat to Think: Big Pharma Wants You to Take Pills Forever. We Don't.”, conducted a satellite media tour to share tips and advice on how to use nutritious food to help support your brain health and cognitive function. A video accompanying this announcement is available at: https://youtu.be/-jYERLSPs80 If you’re over 50, you’re most likely a part of the growing number of people who fear a gradual loss of brain function, otherwise known as cognitive decline or dementia. It’s normal to worry. But there is good news. Cognitive decline is mostly the result of lifestyle choices, not genetics. It is simply a story of “too little/too much “- too little of the nutrients your brain needs daily to maintain health and too much of the foods, drugs, and poor lifestyle choices that damage the brain. Nutrient Survival, the pioneering force in Special Ops Grade nutritional innovation, announces the launch of the book “ Eat to Think,” co-authored by Peter M. Castleman and B. Eric Christianson and available now on Amazon. The book explores the beauty of the brain and how it is designed to regenerate forever while empowering readers with Six Pillars of Brilliance to strengthen brain health and longevity. Both Christianson, CEO of Nutrient Survival, and Castleman, Chairman of Nutrient Institute, a non-profit dedicated to improving human nutrition, were spurred to write “Eat to Think” after researching the damage to human health created by common nutritional habits and an over dependence on “Big Pharma” to address health symptoms versus root issues. “In today’s society we have come to accept the inevitable degeneration of our brains and mental function, which does not need to be our fate,” insists Castleman. “Declining mental faculties with age is typically a product of ‘neuroinflammation,’ a process that gradually damages brain cells but can be reversed with proper nutrition. We have the power to regenerate our brain cells within literal reach of our pantries and refrigerators.” Much of the nutritional science and functional ingredients discussed in “Eat to Think'' are incorporated into Nutrient Survival’s newest BrainCare® product launch, the Brain Omega 3 Bar®. An all-natural solution to support brain performance, each Brain Omega 3 Bar® features a patent-pending combination of 1,948mg of Omega 3s, 40 essential nutrients including 27 vitamins and minerals, naturally occurring flavonoids and 8g of protein, all offering better bioavailability of ingredients to nourish both your brain and body. Brain Omega 3 Bar - Fig & Dark Chocolate contains sweet ripe figs, rich dark chocolate, and tart cranberry pieces. Brain Omega 3 Bar - Fig & Roasted Peanut offers ground peanut with sweet ripe figs, semi-sweet chocolate, and creamy peanut morsels. Both flavors are blended with rolled oats, organic rice crisps, milled flax and hemp seeds and feature the following: ● 1,948 mg of Omega 3 (EPA 430 mg + DHA 323 mg + ALA 1,160mg + SDA 35mg) ● 40 essential nutrients ● 27 vitamins and minerals ● 8g of protein including 1.5g of collagen ● Natural flavonoids from semi-sweet chocolate, figs and peanuts ● No artificial colors, flavors or preservatives ● Gluten free The Brain Omega 3 Bar® is available for $2.75 a bar in bags of 15 at nutrientsurvival.com. For more info on the book visit eattothink.com - About Nutrient Survival Nutrient Survival LLC is an end-to-end food technology company offering nutrient dense survival food for emergencies and every day. Nutrient Survival has experienced explosive growth since its introduction in 2020, behind its patented nutrient dense products and compelling brand proposition. Designed to the same nutritional requirements of the US military for its elite Special Ops units, the brand delivers six times more nutrition than any other survival food brand. Nutrient Survival meals designed using the nutritional standards specified in Department of Defense pubs AR 40-25/OPNAVINST 10110.1/MCO 10110.49/AFI 44–141 for Restricted Rations, those rations intended for use on special operations missions. Meals meet or exceed standards for 23 nutrients on a per calorie basis. Neither the US Armed Forces nor the US Federal Government has approved, endorsed or authorized this product. The opinions expressed are solely those of the individual's. About the Authors Peter M. Castleman. Chairman of Nutrient Survival; Chairman of WISEcode; Chairman of Nutrient Institute. A lifetime entrepreneur who for the past decade has been dedicated to improving human nutrition and information about what is in our foods. Castleman graduated from Duke University at the top of his class in Economics, became a Professor at Harvard, then worked on Wall Street. Castleman bought North Face outerwear company when it was going bankrupt and turned it into a 3 billion per year company and then sold it. He did the same with Igloo, Herbalife, and many others. Castleman aims to empower consumers to manage wellness, instead of being controlled by Big Food, Big Ag, and Big Pharma. With good information, Castleman believes humans can make informed decisions with their lifestyle choices. B. Eric Christianson. CEO of Nutrient Survival; Army Veteran; Airborne Ranger qualified; West Point Distinguished Cadet graduate. After a career of leading iconic food brands at Fortune 100 companies, Christianson found his lifelong calling when he was asked by Castleman to build a company called Nutrient Survival. Born at the start of the pandemic, Nutrient Survival is a disruptive end-to-end food company based in Reno-Tahoe, Nevada, that redefines survival food – and all food for that matter – with performance nutrition. With its patented products, Nutrient Survival brings top shelf, delicious, Special Ops grade nutrition. Designed to the same elite nutritional standards of the military for its Special Operations Forces but intended for people like us. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

February 06, 2024 03:31 PM Eastern Standard Time

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Prodigy Biotech Enters into a Partnership Agreement with Leading Cancer Center to Advance Products to Improve Outcomes in Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation

Prodigy Biotech

Prodigy is the first company to join the MSK Therapeutic Accelerator. The accelerator program launch was announced at the MSK Life Sciences Innovation Summit in New York City on January 26, 2024. Prodigy and Memorial Sloan Kettering Cancer Center (MSK) will co-develop a product targeting Enterococcus sp. to treat microbial dysbiosis in patients undergoing allogenic hematopoietic stem cell transplantation. The product will be built on Prodigy’s polyclonal Immunoglobulin Y (IgY) technology that has shown promising preclinical data in models of alcoholic liver disease. Prodigy and MSK have entered into a sponsored research agreement through the MSK Therapeutics Accelerator program to evaluate Prodigy’s product candidate for the improvement of outcomes in patients undergoing allogenic hematopoietic stem cell transplantation (allo-HCT). The MSK Therapeutic Accelerator project will be led by Jonathan Peled, MD, PhD, Assistant Attending Physician, MSK. Through his pioneering research, Dr. Peled and his team at MSK have significantly advanced the role of the microbiome in impacting outcomes in patients undergoing allo-HCT. Dr. Peled’s work revealed that patients undergoing allo-HCT have enterococcal domination events and these domination events lead to worse overall survival and higher graft vs. host disease (GvHD)-related mortality. Dr. Peled has previously demonstrated in preclinical models that resetting the gut microbiome has profound outcomes in mitigating disease severity. In this collaboration, Prodigy’s Enterococcus sp. neutralizing antibodies will be evaluated in preclinical models of GvHD and product candidates will be developed to move into clinical development. Furthermore, Prodigy is pleased to have Dr. Peled join and help build its allo-HCT Scientific Advisory Board (SAB). In addition to the sponsored research, MSK will provide expertise and institutional resources through the MSK Therapeutics Accelerator to aid in the development of a drug candidate for patients undergoing allogenic hematopoietic stem cell transplantation. MSK’s Therapeutic Accelerator Program is a partnership program between MSK and technology and pharmaceutical companies to advance novel therapeutics through all stages of drug development. The program brings together innovative healthcare companies with MSK’s community of clinical and scientific experts to establish groundbreaking collaborations that can have a tangible impact on treatment or management of cancer. Satish Chandran, CEO of Prodigy said, “ We are delighted to collaborate and partner with MSK’s Therapeutic Accelerator Program and Dr. Peled to develop product(s) for patients undergoing allo-HCT. Given the significant morbidity and mortality associated with the disease, it is incumbent upon all of us to find solutions that have the potential to save lives and restore normalcy to these patients. We have been very pleased with the robust preclinical proof-of-concept data of our product PROD-AH-001, (Hepatology, 2023) for alcoholic hepatitis which is currently being readied for an IND submission with the FDA.” Dr. Jonathan Peled of MSK said, "Patients who are treated with allo-HCT experience the most extreme microbiome injuries observed in any clinical setting. There is an urgent need to develop approaches that can mitigate this and prevent the expansion of potentially pathogenic bacteria. We hypothesize that attenuating the expansion of Enterococcus within the gastrointestinal tract will prevent bloodstream infections with this bacterium and potentially also ameliorate GVHD.” Dr. Chandran presented information about this important new collaboration at the MSK Life Sciences Innovation Summit in New York City on January 26, 2024. About Allogenic Hematopoietic Stem Cell Transplantation Allo-HCTs have a chance to cure malignancies but are associated with high rate of complications and mortality. Allo-HCT can lead to various complications, affecting different organs due to the intense conditioning regimen and introduction of foreign immune cells. A significant concern after allo-HCT is graft-versus-host disease (GvHD), where the donor's immune cells mount an attack against the recipient and is a major cause of morbidity and non-relapse mortality in this patient population. There is a clear need of therapies that are able to improve outcomes in patients undergoing allogenic hematopoietic stem cell transplantation. About Prodigy Biotech, Inc. Prodigy Biotech is a privately held biopharmaceutical company focused on developing products using its polyclonal Immunoglobulin Y technology to selectively edit the microbiome while avoiding deleterious effects to the commensal microflora. The versatility of avian antibodies, IgY, allows for pathogen- specific neutralization capabilities not only to bacteria but also viruses, fungi, endotoxins, and even human secreted proteins such as cytokines and chemokines. A target agnostic approach and strategic collaborations with leading researchers in the microbiome field has allowed Prodigy to build a diverse pipeline ranging from modulating the gut microbiome in alcoholic liver disease (ALD) to modulating the lung microbiome in chronic obstructive pulmonary disease (COPD). Cautionary Note on Forward-Looking Statements: This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995, which are subject to risks and uncertainties. We may, in some cases, use terms such as “predicts,” “believes,” “potential,” “proposed,” “continue,” “estimates,” “anticipates,” “expects,” “plans,” “intends,” “may,” “could,” “might,” “will,” “should” or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from our current expectations. Any forward-looking statements that we make in this press release speak only as of the date of this press release. Except as required by law, we assume no obligation to update forward-looking statements contained in this press release whether as a result of new information, future events or otherwise, after the date of this press release. Contact Details Prodigy Biotech, Inc. Satish Chandran satish.chandran@prodigybiotech.com Company Website https://www.prodigybiotech.com/

February 06, 2024 10:00 AM Eastern Standard Time

Doceree Secures Patent for its Groundbreaking Technology Empowering Marketers to Elevate Patient-Physician Engagement Through Real-Time Triggers on EHR Platforms

Doceree

Doceree, the leading global healthcare marketing platform building unprecedented solutions for programmatic HCP marketing using proprietary data tools, today announced the grant of a patent by US Patent and Trademark Office (USPTO) for its distinguished feature ‘Triggers’ that uses clinical data as real-time prompts for messaging to HCPs on Electronic Health Record Platforms, in a HIPAA-compliant and privacy-forward way. In the United States, physicians possess the potential to enhance healthcare delivery by leveraging relevant information; however, the challenge lies in the timely accessibility of crucial data. Despite the ongoing digital transformation in the healthcare sector, Healthcare Professionals (HCPs) continue to face a notable gap in accessing up-to-date information, a resource that is currently exclusive to life sciences organizations. As the industry undergoes rapid digitization, the need for efficient information dissemination to empower healthcare providers becomes increasingly evident. Bridging this information gap, Doceree introduced Triggers- a technological solution designed to guarantee the delivery of optimal and well-informed care to patients. Doceree's groundbreaking patent, officially paves the way for the integration of Doceree Triggers into the pharmaceutical marketing landscape. This patent encompasses a sophisticated medical product processing system that employs a first graphical user interface connected to an Electronic Health Record (EHR) platform. The system is designed to display messages in real-time to medical providers, tailored to their patients' predefined conditions. These conditions are inputted into the patient's electronic health record during the interaction between the patient and the healthcare provider, encompassing crucial details such as definitions of international classifications of diseases (ICD) codes. This patent not only represents a pivotal achievement, affirming Doceree's pioneering strategy in revolutionizing the interaction between pharmaceutical marketing and healthcare professionals, but it also plays a crucial role in aiding Electronic Health Record (EHR) platforms. The patent ensures real-time clinical data mapping in a HIPAA-compliant manner, contributing to the optimization of EHRs for health data interoperability. This optimization holds significant importance in supporting clinical research efforts. The seamless integration of research and clinical care within a health system has the potential to boost clinical trial participation rates, enhance health outcomes, reduce the cost of care, and foster greater patient satisfaction. " This patent not only signifies our steadfast dedication to pushing the boundaries and creating pioneering solutions for addressing the industry's most intricate challenges but also stands as a significant milestone in our journey towards establishing leadership in healthcare innovation and technology," stated Harshit Jain MD, Founder, and Global CEO of Doceree. " Beyond its legal implications, this inaugural patent reflects the resilience and forward-thinking ethos that defines our company. It serves as the bedrock for sustained success in the ever-evolving landscape of innovation, embodying our commitment to continuous advancement. The issuance of this patent is a powerful reminder of what can be achieved through collaborative efforts and a shared dedication to our strategic objectives," he emphasized. Doceree Triggers stands out by offering pharmaceutical manufacturers a distinctive set of capabilities. It enables the strategic planning and coordination of healthcare provider and direct-to-consumer campaigns, leveraging comprehensive insights into patient and provider behaviors, including the evaluation of past and present script performance. The platform empowers users to activate media seamlessly across various channels, encompassing display, video, and connected TV, all while optimizing bids to enhance overall business outcomes. Real-time performance measurement is a key feature, providing immediate insights into each campaign's effectiveness. Moreover, Doceree Triggers facilitates the dynamic optimization of ongoing campaigns by automatically adjusting parameters, enhancing audience quality, boosting script lift, and maximizing overall media efficiency. This multifaceted approach ensures that pharmaceutical marketing efforts are not only well-informed but also agile and responsive, driving impactful results in the competitive landscape. About Doceree: Doceree is a global platform building unprecedented solutions for healthcare professional (HCP) messaging with proprietary data and advanced tools. Utilizing an extensive global network of digital endemic and point-of-care platforms, Doceree facilitates seamless and meaningful communication between life sciences brands and HCPs, ensuring delivery of highly personalized messages to HCPs at scale. To learn more, https://doceree.com/us/doceree-triggers/. Contact Details Doceree Priyanka Bhasin +91 78387 03702 priyanka.bhasin@doceree.com Doceree Tanya Singh +91 70420 89805 tanya.singh@doceree.com Company Website https://doceree.com/us/doceree-triggers/

February 06, 2024 09:00 AM Eastern Standard Time

Elicio Therapeutics Announces Publication of Preclinical Data Demonstrating Power Of Amphiphile-Immunotherapy

Benzinga

By Jeremy Golden, Benzinga A clinical-stage biotechnology company has published promising preclinical data in Cancer Immunology Research, a journal of the American Association for Cancer Research (AACR). The data produced by Elicio Therapeutics Inc. (NASDAQ: ELTX) demonstrates how Elicio’s proprietary Amphiphile (AMP) lymph node-targeting immunotherapy platform, carrying cognate peptide and adjuvant cargos, boosted T cell receptor-modified T cell (TCR-T cell) therapies while enhancing anti-tumor function and eradicating solid tumors. According to Peter DeMuth, Ph.D., Chief Scientific Officer at Elicio Therapeutics, optimization of TCR-T cell therapy could potentially have wide-ranging therapeutic benefits in many previously intractable solid tumors. During the study, AMP immunotherapy enhanced the infiltration and function of TCR-T cells in the tumor microenvironment and led to epitope spreading against diverse tumor targets. Additionally, long-term protection against tumor recurrence in AMP-treated mice was associated with antigen spreading to additional tumor-associated antigens not targeted by the treatment. “In this study, we’ve demonstrated that boosting TCR-T cell therapy directly in the lymph nodes with AMP immunotherapy resulted in durable anti-tumor T cell responses and tumor eradication,” DeMuth said. “The AMP treatment uniquely promoted potent mechanisms for immune activation in lymph nodes to invigorate both adoptive and endogenous anti-tumor T cell immunity. Simple application to a variety of cancer targets including mKRAS, HPV E7 and NY-ESO-1 could elevate existing TCR-T cell therapies to generate powerful new combinations for hard-to-treat solid tumors.” Elicio Therapeutics is developing a pipeline of novel immunotherapies for the treatment of cancer. Three vaccine candidates are currently in Elicio Therapeutics’ pipeline: ELI-002, ELI-007 and ELI-008. Elicio’s proprietary AMP platform delivers investigational immunotherapeutics directly to the lymph nodes, sometimes referred to as the “brain center” of the immune system. In previous Elicio studies, the results found that AMP immunotherapy promoted specific trafficking and retention of payloads into lymph nodes, yielding enhanced T cell numbers, persistence and functional quality. Preliminary phase 1 data from the ongoing study of Elicio’s lead asset, ELI-002, demonstrated significant T cell responses – including both CD4+ and CD8+ – when administered as an adjuvant monotherapy in patients with pancreatic and colorectal cancers. The strength of the T cell response induced by ELI-002, an mKRAS-specific AMP vaccine, was further correlated to significant improvements in tumor biomarker response, along with reduced risk of progression and death. This indicates an association between the ELI-002 mechanism of action and clinical outcome. “This study adds to our growing body of preclinical and clinical evidence demonstrating the importance of the lymph nodes and the robust efficacy that our AMP immunotherapy strategy can potentially achieve for patients with solid tumors, both as a monotherapy and in combination with other strategies,” said Robert Connelly, Chief Executive Officer at Elicio Therapeutics. “The AMP platform provides attractive potential for broad and rapid application to clinical and developmental TCR-T cell programs. We look forward to finding the right partner to advance this promising combination into the clinic for patients with solid tumors.” Featured photo by National Cancer Institute on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

February 06, 2024 08:35 AM Eastern Standard Time

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CytoReason’s AI-Driven Disease Model Platform Trusted By 5 Top 10 Pharma Companies Harnesses Big Data To Speed Drug Discovery And Development

OurCrowd

By Meg Flippin, Benzinga Click here to learn more about CytoReason and how to invest through OurCrowd. Big data is transforming everything from the way we drive to the way we shop or even the way we consume energy. But when it comes to healthcare and fighting diseases, it still takes 10 or more years to bring a drug or treatment to market. What’s more, 90% of drugs in development fail. A big reason is that all the disparate data being collected from doctors, hospitals, clinical trials and patient outcomes reside in silos – thus not functioning together, and that only seems poised to get worse. The volume of human molecular data is growing rapidly, but analytic capabilities aren’t keeping up. That is essentially slowing progress in finding potential cures and more effective treatments. To overcome this challenge, a platform that can digest, organize and make sense of all the different data types and sources is needed – and that’s where CytoReason and its Disease Model Platform come in. Founded in 2016 to address this problem, CytoReason created what the company says is the first AI model to map treatments, patient groups and disease mechanisms while constantly evolving and learning. Bringing It All Together Researchers of all levels can rely on CytoReason’s proprietary data and innovative technology to make data-driven decisions across the drug development life cycle. Scientists can identify potential targets, prioritize indications, and stratify patient populations. Program leaders can compare drugs across multiple diseases or multiple drugs within a single disease. C-level executives can gain valuable tools to manage and optimize entire drug portfolios. Never before has there been that much data organized and analyzed on one platform, says CytoReason. Similar to how navigation apps provide layers of data about streets, buildings and addresses, CytoReason's Disease Model Platform offers layers of pre-computed data, which can include results from clinical trials, data on proteins and single-cell data. With multiple models for various diseases, users of the platform can identify potential targets, prioritize treatments, stratify patients and find possible drug combinations. User-generated data can also be integrated, and hypotheses across different treatments can be tested. The platform learns with you and can help you understand the cause of the disease and identify potential R&D avenues for prevention. Giving Pharma An Edge For drug development companies and researchers, CytoReason says the biggest advantage of its Disease Model Platform is its ability to compare assets across different diseases. With a single standard for all disease models, users can answer critical questions including which patients may benefit most from the drug, what other diseases the drug can be developed for, and how the drug stacks up against the drugs currently available. By answering those questions, decision-makers in pharma and biotech companies can find new opportunities, increase success rates and shorten the drug development cycle. Sounds too good to be true? The platform is already being used by five of the top ten pharma companies including Sanofi SA (NASDAQ: SNY), Pfizer Inc. (NYSE: PFE). Sanofi, which tapped CytoReason’s AI platform for use in the field of inflammatory bowel disease (IBD) expanded its multiyear collaboration last year. Sanofi is using the platform to identify patient subtypes and pair them with IBD targets. Under the terms of the expanded agreement, Sanofi will pay CytoReason an undisclosed multimillion-dollar amount. Pfizer, which has been working with CytoReason since 2019, also extended its collaboration, announcing in 2022 that it committed a $20 million equity investment, has options to license CytoReason’s platform and disease models and fund supplementary project support in a deal potentially worth up to $110 million over the next five years. Since the two began collaborating, Pfizer has used CytoReason's biological models in its research to enhance the understanding of the immune system as it develops innovative drugs for immune-mediated and immuno-oncology diseases. CytoReason's platform has provided Pfizer with multiple insights in its research and development programs across over 20 diseases. CytoReason’s platform has also benefited Poolbeg Pharma, which has been using it to find novel approaches for treating influenza. Poolbeg’s disease progression data from influenza human challenge trials combined with CytoReason’s disease model platform led to the discovery of multiple novel drug targets for the treatment of influenza. Big data is growing exponentially, particularly in the healthcare field, but getting it under one roof has proven difficult. It's the reason it takes so long to develop drugs and why the majority of them fail. Platforms like CytoReason are working to change that, providing AI-generated insights to understand disease mechanisms and disease progression, as well as potential treatment methods. In a world where data is endless, CytoReason is making sense of it all. To learn more about CytoReason and its novel approach to data click here. OurCrowd was started in 2013, driven by the idea that the business of building startups grows bigger and better when the global ‘crowd’ gains access to VC-level investment opportunities.Today, OurCrowd is a global venture and alternative investing platform that empowers institutions and individuals to invest and engage in emerging companies. OurCrowd vets and selects companies, invests its capital, and provides its global network with unparalleled access to co-invest and contribute connections, talent and deal flow. OurCrowd builds value for its portfolio companies throughout their lifecycles, providing mentorship, recruiting industry advisors, navigating follow-on rounds and creating growth opportunities through its network of multinational partnerships. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Lisa Graston lisa.graston@ourcrowd.com Company Website http://www.ourcrowd.com

February 06, 2024 08:10 AM Eastern Standard Time

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