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Simple tips and tricks to tackle inflation and manage budgets this Back-To-School shopping season

YourUpdateTV

A recent poll from Morning Consult found that only 36% of parents can afford back-to-school shopping this year without any issues. The National Retail Federation’s latest back-to-school shopping survey also shows a third of families plan to cut back on other spending areas — in order to cover the cost of must-haves for the new school year. Even with so many people concerned about costs, back-to-school spending is expected to hit an all time high this year — a whopping $864 per household for K-12, and $1200 for college students. Despite all of these challenges, there are some simple tips and tricks to save every penny you can for back-to-school shopping and beyond: Look for Student and Seasonal Discount: Flash your student ID and many popular stores will give you discounted rates. You can also take advantage of student discounts through sites such as Unidays and Student Beans. College students usually get the most discounts but many stores have savings for grades K-12 too. Spread Out Payments Over Time with Reliable Buy Now, Pay Later Options: With rising costs, many consumers are looking for greater payment flexibility when making back-to-school purchases. Pay Later with PayPal lets you spread payments out over time. For purchases between $30-$1,500, you can select Pay in 4 1 and break the cost into four interest-free payments with the first payment due at time of purchase. For those larger back-to-school purchases, you can select the new Pay Monthly 2 option and break the total cost into monthly payments over a longer period of time. Pay Later with PayPal gives you more choice in how you pay for purchases so you can select the option that works best for your budget. Learn more at paypal.com/buynowpaylater. Use browser extensions for coupons and cash back: You might think you’ve found the best deal out there, but there’s a good chance there are even better prices still waiting to be discovered. The Easiest way to make sure you’re paying the lowest prices — is to Install the PayPal Honey 1 desktop “browser” extension. This online shopping tool automatically discovers coupons at your favorite stores— and applies the best ones it finds at checkout. It even helps you layer savings by finding rewards that you can redeem for cash back. You can find it at: www.joinhoney.com Shop Refurbished: There are plenty of apps and sites out there to help you track down any used or refurbished items on your list. Whether you’re shopping for textbooks, electronics or clothing, you’ll pay less than if you were to buy the item brand new. Plus, you can usually find discounted items in “like new” condition on many platforms for free.. Contact Details Your Update TV +1 212-736-2727 yourupdatetv@gmail.com

August 31, 2022 02:20 PM Eastern Daylight Time

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The Chicago School of Professional Psychology Partners With University of Guadalajara to Develop Courses, Training

The Chicago School of Professional Psychology

The Chicago School of Professional Psychology has established a partnership with one of the largest universities in Mexico to develop courses, conferences, symposia and training programs for students on both sides of the border. A memorandum of understanding was signed Saturday in Los Angeles with The University of Guadalajara and The University of Guadalajara Foundation USA. “We are excited to begin joint academic, scientific and cultural collaborations to provide cross-cultural, international exchanges,” said Dr. Michele Nealon, President of The Chicago School of Professional Psychology. “This agreement will bring new resources to both universities, so that we can work together to train the next generation of culturally competent mental health professionals to serve our communities.” The agreement was signed during the Spanish Book Fair and Literary Festival LéaLA in Los Angeles, an event sponsored annually by the foundation. Founded in 1979, The Chicago School of Professional Psychology is a private, not-for-profit university dedicated to training culturally competent professionals who can fundamentally improve the health and well-being of a generation of diverse communities. It has seven campuses located in Chicago, Los Angeles, Anaheim, San Diego, Dallas, New Orleans, Washington D.C., and online. The University of Guadalajara is one of the oldest and largest educational institutions in Latin America. Currently, the University encompasses six thematic university centers, nine regional university centers, and secondary education system. It boasts 165 campuses distributed throughout Jalisco, as well as an extensive online program. The UDG Foundation USA is a non-profit public benefit corporation incorporated in the United States of America that promotes the academic and cultural offerings of the University of Guadalajara in favor of the educational advancement of the Mexican community in the Los Angeles region, California, United States of America through the development of fundraising campaigns and actions.# About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. TCSPP continues to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, nursing, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of international partner institutions, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is a proud affiliate of TCS, a nonprofit system of colleges advancing student success and community impact. To learn more, visit www.thechicagoschool.edu. Contact Details Vivien Hao +1 323-893-4743 vhao@thechicagoschool.edu

August 31, 2022 06:00 AM Eastern Daylight Time

Volatus Aerospace Corp. Announces Record Second Quarter 2022 Sales of $6.6M and Provides Corporate Update

Volatus Aerospace Corp.

Volatus Aerospace Corp. (TSXV: VOL) (OTCQB: VLTTF) ("Volatus" or "the Company"), a global leader in the drone industry, is pleased to announce its financial results for the quarter ending June 30, 2022 ("Q2 2022"). The revenue increase in Q2 2022 was driven by strong organic growth, expansion into the defense segment, geographic expansion, and higher services and training revenue. The Company generated revenue of $11,437,421 in the first half of 2022. The first two quarters have seasonality for drone services and training, and the third quarter is expected to be the strongest in these segments. Key Financial Highlights: Revenue for Q2 2022 was $6,629,593, an increase of 38% over the previous quarter and a 95% increase over the same quarter prior year. Gross profit for Q2 2022 was $1,900,920 an increase of $943,968 over the same period in 2021. The increase in gross profit was due to scale in product and services activities. Volatus recorded a comprehensive loss of ($1,626,896). This was due to increased investment in human resources in the defense and integrated solutions segment, and increased advertisement and marketing expenses. The Company has experienced a gross margin of 29% representing an increase of 6% over the first quarter of 2022. Contributing to increased margins are revenue from product diversification, and higher margins from services and training. Notable Operational Accomplishments During the Quarter: Continued delivery of ISR (Intelligence, Surveillance, and Reconnaissance) Drones to Ukraine Addition of several ISR products for defense and public safety The strategic acquisition of Canadian Air National Inc., which performs aerial pipeline inspections Launch of Latin America joint venture Introduction of Volatus AERIEPORT, an autonomous drone nesting station Signed numerous partnerships with OEMs to diversify and commercialize product offerings Announcement of a commercial training agreement with Moose Cree First Nations Appointment of Lt. General (Ret’d) The Honorable Andrew Leslie to the Board of Directors "I am pleased with the continued progress of our team as they continue to execute our plan toward a sustainable and profitable future,” said Glen Lynch, CEO of Volatus Aerospace. “Our investments in the defense and public safety sectors are beginning to gain traction and the introduction of the AERIEPORT and other Volatus technology solutions will help drive higher margin sales in the future.” The condensed consolidated interim financial statements for the three months ended June 30, 2022, and associated management discussion and analysis, are available under the Company's profile on SEDAR at www.sedar.com. This news release is not in any way a substitute for reading those financial statements, including the notes to the financial statements. Webinar In conjunction with this release, Volatus investor relations will host a webinar on Tuesday, August 30 th at 4:30 PM EST at which time Glen Lynch, Chief Executive Officer, and Abhinav Singhvi, Chief Financial Officer, will review the quarterly results and major milestones with Rick Peterson, CEO of Peterson Capital, as moderator. Investors are invited to register for the webinar here. https://us06web.zoom.us/webinar/register/WN_DQE4_KNfR9CdqWJ4CEIkkQ Audio Replay Options An audio replay of the event will be archived on the Investor Relations page of the company's website here CORPORATE UPDATE The Brokered Private Placement Volatus is pleased to announce that it has engaged Echelon Wealth Partners Inc. (the “Lead Agent”) and Integral Wealth Securities Limited (“Integral”, and together with the Lead Agent, the “Agents”) on a commercially reasonable best efforts private placement for the sale of up to 1,388,888 units of the Company (the “Units”) in the Province of Quebec at a price of $0.36 per Unit (the “Offering Price”) for aggregate gross proceeds of up to $500,000 (the “Offering”). Each Unit will be comprised of one common share in the capital of the Company (each, a “Common Share”) and one common share purchase warrant (a “Warrant”), with each Warrant being exercisable to acquire one Common Share at a price of $0.50 per share for a period of 24 months following the issuance thereof. The proceeds derived from the sale of the Units will be used for (i) inventory purchases and increasing factory operations; (ii) R&D and capital expenditure, (iii) future acquisitions and (iv) and for working capital and general corporate purposes. In consideration of the services rendered by the Agents in connection with the Offering, the Company has agreed to pay to the Agents on the closing date a commission equal to 8% of the gross proceeds from the Offering. In addition, the Company will issue the Agents warrants (the “Agents’ Warrants”) to acquire that number of Units which is equal to 8.0% of the number of Units sold under the Offering, at an exercise price equal to the Offering Price. The compensation to the Agents on certain subscriptions on a president’s list of up to $500,000 shall be reduced to 3% Cash Commission and 3% Agents’ Warrants. About Volatus Aerospace: Volatus Aerospace Corp. is a leading provider of integrated drone solutions throughout Canada, the United States, Latin America and most recently in Europe. Operating a vast pilot network, Volatus serves commercial and defense markets with imaging and inspection, security and surveillance, equipment sales and support, training, and design, manufacturing, and R&D. Through its subsidiary Volatus Aviation, Volatus carries on the business of aircraft management, charter sales, and cargo services using piloted, remotely piloted, and autonomous aircraft. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accept responsibility for the adequacy or accuracy of this release. Forward-Looking Statement This news release contains statements that constitute “forward-looking information” within the meaning of applicable securities laws, including statements regarding the plans, intentions, beliefs and current expectations of the Corporation with respect to future business activities and operating performance. Often, but not always, forward-looking information can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or variations (including negative variations) of such words and phrases, or statements formed in the future tense or indicating that certain actions, events or results “may”, “could”, “would”, “might” or “will” (or other variations of the foregoing) be taken, occur, be achieved, or come to pass. Forward-looking information includes information regarding (i) the business plans and expectations of the Corporation; and (ii) expectations for other economic, business, and/or competitive factors. Forward-looking information is based on currently available competitive, financial and economic data and operating plans, strategies or beliefs as of the date of this news release, but involve known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, performance or achievements of the Corporation to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information. Such factors may be based on information currently available to the Corporation, including information obtained from third-party industry analysts and other third-party sources, and are based on management’s current expectations or beliefs. Any and all forward-looking information contained in this news release is expressly qualified by this cautionary statement. Investors are cautioned that forward-looking information is not based on historical facts but instead reflects expectations, estimates or projections concerning future results or events based on the opinions, assumptions and estimates of management considered reasonable at the date the statements are made. Forward-looking information reflects the Corporation’s current beliefs and is based on information currently available to it and on assumptions it believes to be not unreasonable in light of all of the circumstances. In some instances, material factors or assumptions are discussed in this news release in connection with statements containing forward-looking information. Such material factors and assumptions include, but are not limited to: the impact of the COVID-19 pandemic on the Corporation; meeting the continued listing requirements of the TSXV; and anticipated and unanticipated costs and other factors referenced in this news release and the Circular, including, but not limited to, those set forth in the Circular under the caption “Risk Factors”. Although the Corporation has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. The forward-looking information contained herein is made as of the date of this news release and, other than as required by law, the Corporation disclaims any obligation to update any forward-looking information, whether as a result of new information, future events or results or otherwise. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information. Source: Volatus Aerospace Corp. TSXV: VOL Contact Details Abhinav Singhvi +1 833-865-2887 abhinav.singhvi@volatusaerospace.com Company Website https://volatusaerospace.com

August 29, 2022 04:30 PM Eastern Daylight Time

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Amesite Announces Partnership with Central Michigan University to Deliver a Complete Upskilling Solution

Amesite Inc.

Contact Details Amesite, Inc. +1 734-876-8141 info@amesite.com Company Website http://www.amesite.io

August 29, 2022 10:00 AM Eastern Daylight Time

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The Chicago School of Professional Psychology Awarded $260K

The Chicago School of Professional Psychology

The Chicago School of Professional Psychology announced it has been awarded $260,000 as part of the Ronald E. McNair Postbaccalaureate Achievement Program, a federal government initiative for colleges and universities to assist low-income, first-generation college students and individuals with disabilities. The U.S. Department of Education earlier this month set aside $51.7 million in 189 new grant awards to institutions of higher education such as The Chicago School to provide disadvantaged college students effective preparation for doctoral studies. “We are excited to implement new programs that will further set up our students for success in school and in their chosen professions,” said Dr. Michele Nealon, President of The Chicago School of Professional Psychology. “We are deeply invested in enlarging the pipeline of mental health professionals who will go on to work in underserved communities where they are needed most.” Through McNair grant funding, The Chicago School will offer research or other scholarly activities, such as summer internships and seminars to students. McNair-funded initiatives also prepare students for doctoral study through tutoring, academic counseling, and assistance with securing admission to and financial assistance for enrollment in graduate programs. McNair projects may also fund financial and economic literacy of students, mentoring programs, and exposure to cultural events and academic programs not usually available to disadvantaged students. The Chicago School is a majority minority-serving institution serving more than 6,000 students, maintains campuses in six major metro areas and an online program. Two-thirds of its students identify as people of color. About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. To spark positive change in the world where it matters most, The Chicago School has continued to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of domestic and international professional partnerships, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is proud to be a part of TCS Education System, a nonprofit, integrated system of colleges and universities that work collaboratively to advance student success and community impact. To learn more, visit www.thechicagoschool.edu. About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. TCSPP continues to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, nursing, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of international partner institutions, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is a proud affiliate of TCS, a nonprofit system of colleges advancing student success and community impact. To learn more, visit www.thechicagoschool.edu. Contact Details Vivien Hao +1 323-893-4743 vhao@thechicagoschool.edu

August 26, 2022 06:00 AM Pacific Daylight Time

The Chicago School of Professional Psychology Awarded $260K For Students

The Chicago School of Professional Psychology

The Chicago School of Professional Psychology announced it has been awarded $260,000 as part of the Ronald E. McNair Postbaccalaureate Achievement Program, a federal government initiative for colleges and universities to assist low-income, first-generation college students and individuals with disabilities. The U.S. Department of Education earlier this month set aside $51.7 million in 189 new grant awards to institutions of higher education such as The Chicago School to provide disadvantaged college students effective preparation for doctoral studies. “We are excited to implement new programs that will further set up our students for success in school and in their chosen professions,” said Dr. Michele Nealon, President of The Chicago School of Professional Psychology. “We are deeply invested in enlarging the pipeline of mental health professionals who will go on to work in underserved communities where they are needed most.” Through McNair grant funding, The Chicago School will offer research or other scholarly activities, such as summer internships and seminars to students. McNair-funded initiatives also prepare students for doctoral study through tutoring, academic counseling, and assistance with securing admission to and financial assistance for enrollment in graduate programs. McNair projects may also fund financial and economic literacy of students, mentoring programs, and exposure to cultural events and academic programs not usually available to disadvantaged students. The Chicago School is a majority minority-serving institution serving more than 6,000 students, maintains campuses in six major metro areas and an online program. Two-thirds of its students identify as people of color. About The Chicago School of Professional Psychology Integrating theory with hands-on experience, The Chicago School of Professional Psychology provides education rooted in a commitment to innovation, service, and community for thousands of diverse students across the United States and globally. Founded in 1979, the nonprofit, regionally accredited university now features campuses in iconic locations across the country (Chicago, Southern California, Washington, D.C., New Orleans, Dallas) and online. To spark positive change in the world where it matters most, The Chicago School has continued to expand its educational offerings beyond the field of psychology to offer more than 30 degrees and certificates in the professional fields of health services, education, counseling, business, and more. Through its engaged professional model of education, commitment to diversity and inclusion, and an extensive network of domestic and international professional partnerships, The Chicago School’s students receive real-world training opportunities that reflect their future careers. The Chicago School is proud to be a part of TCS Education System, a nonprofit, integrated system of colleges and universities that work collaboratively to advance student success and community impact. To learn more, visit www.thechicagoschool.edu. Contact Details The Chicago School of Professional Psychology Vivien Hao +1 323-893-4743 vhao@thechicagoschool.edu The Chicago School of Professional Psychology Victor Abalos +1 818-321-5371 vabalos@thechicagoschool.edu

August 26, 2022 06:00 AM Pacific Daylight Time

Minuteman Press Franchise in Swindon, England Reopens Doors After Flooding and Fire

Minuteman Press International Inc

Minuteman Press in Swindon, England has reopened its physical location at 19-21 Newport Street (Ground Floor – Newport House). After suffering water damage from flooding in July of 2021 and electrical fire damage in October of 2021, owner James Beckwith and his team continued to operate and serve clients as repairs were being made. James shares, “The community has been fantastic, we officially remained open the whole time taking orders from the website and emails, as well as keeping our phone lines open. We have had nothing but positive comments and folks telling us they are so happy we are back open. Some customers have commented that though they had to go elsewhere for a time, the quality of the print and the quality of the service just didn’t compare to what they received when working with us.” During this critical time and leading to the reopening of their facility, James was grateful to be part of the Minuteman Press franchise family, who stepped in and provided crucial support in many areas. James says, “Mark Jones (UK South Regional VP) and Richard Myers (local field rep) and Duncan Diesel (at MPIHQ) have been invaluable to us. I routinely spoke with Duncan on equipment decisions when ours was being replaced as well as marketing ideas and technical help with Minuteman Press FLEX software and the new website. Richard has been out to see us during the time we had no premises to work up a plan once we were back open and he has been out since opening to assist with production processes and marketing ideas. Mark Jones was always at the end of the phone if we needed advice on anything. He was very key in us making the decision to stay in our current premises when we were investigating moving locations.” Being part of the Minuteman Press system also enabled James to receive vital support from choice vendors like Xerox. James states, “I want to particularly give a shout out to Xerox. They were amazing throughout the entire process. The Xerox kit was always the most expensive shop item and there were lots of negotiations on price to replace the two Versants that were damaged. They ultimately gave us the opportunity to acquire the Xerox Iridesse and offline booklet maker to match the requirements from the two previous Versants while keeping the insurance company happy on cost. Xerox also gave me near free reign of their Uxbridge HQ where I was allowed to run one particular job on their presses every month for six or seven months.” Today, with the repairs finished, new equipment in place and new signage installed, James is excited about the upgrades that have been made to the business. He says, “Our offices and production area have been refurbished, and we can now provide more services than before.” James continues, “We now have totally new kit, and because it is so versatile, we can offer more options than before, with an even faster turnaround. The new Xerox Iridesse is a full production press allowing us more and faster capabilities as well as improved image quality over our previous presses.” He adds, “Even our booklet-making capacity has improved. Whereas before, making a large number of booklets could take several hours, we can now produce up to 3,000 booklets in an hour.” James further explains the benefits of the new equipment installed at Minuteman Press in Swindon: “The Iridesse is absolutely amazing. The image quality is second to none. The job that I would run at Xerox HQ was a monthly magazine run for a local village. 1050 copies, ranging from 20 – 32 pages each month. On our Versants, the job would take 6 – 8 hours. Now the entire job takes us about 2 hours!” We were able to update our Duplo 615 to the 618 and that piece of kit is a dream. Touch screen, easy to configure and very dependable. We replaced our SureColour T5200 with the same model, however now we have the large format scanner which was one area we were sorely lacking. Customers would routinely come in with paper plans looking to get copies or scans and we would have to turn them away, now we can handle the full job for them. We replaced our HP Latex 330 with the Latex 335 that has the Print & Cut feature. We couldn’t be happier with the decision. We are still getting our feet wet with the Print & Cut, but so far we are producing work on all the new kit.” Minuteman Press in Swindon also plans to re-add dye sublimation and add a self-service area for walk-in customers who need a simple print job. James says, “This is really ideal if someone wants a return label printed, for example. We always offered this kind of service for customers, but soon they will be able to do it on a DIY basis.” James concludes, “We are happy to be back in our new and improved facility, and we are excited to continue to welcome back our clients. We are so thankful for them and all of the help we’ve received from our community and MPIHQ, and now we are ready to serve our clients better than ever before.” For more information about Minuteman Press in Swindon, visit https://minuteman.com/uk/locations/england/swindon/ To learn more about #1 rated Minuteman Press franchise opportunities and to see Minuteman Press franchise reviews, visit https://minutemanpressfranchise.co.uk or https://minutemanpressfranchise.com Contact Details Chris Biscuiti +1 631-249-1370 cbiscuiti@mpihq.com Company Website https://minutemanpressfranchise.com

August 26, 2022 05:00 AM Eastern Daylight Time

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Hong Kong Baptist University scientists develop versatile compound for treating Alzheimer’s disease

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 24 August 2022 - A study led by researchers from Hong Kong Baptist University (HKBU) has demonstrated that a multifunctional organic compound named F-SLOH has the potential to treat Alzheimer’s disease (AD) at an early stage. The team found that it can inhibit the aggregation of amyloid-beta (Aβ), and reduce the hyperphosphorylation of tau proteins and neuroinflammation in the brain to improve the pathological features of AD. The findings have been published in the international academic journal Redox Biology. The study conducted by Professor Li Min (left), Professor Ricky Wong Man-shing (right) and Dr Iyaswamy Ashok (middle) provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. AD is the most common cause of dementia. It accounts for nearly 65% of dementia cases in elderly Hong Kong Chinese. It is pathologically characterised by the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerve cells in the brain, which cause progressive neuronal loss and cognitive impairment. Currently there is no cure for AD, and the available medicines can only relieve its symptoms. Inhibiting the abnormal aggregation of Aβ and the hyperphosphorylation of tau proteins is considered the primary and a promising therapeutic approach to treat AD. F-SLOH as theragnostic agent for AD In the search for novel therapeutic and diagnostic methods for AD, a research team comprising Professor Li Min, Professor of the Teaching and Research Division and Associate Dean of the School of Chinese Medicine; Professor Ricky Wong Man-shing, Professor of the Department of Chemistry of the Faculty of Science; and Dr Iyaswamy Ashok, Research Assistant Professor of the Teaching and Research Division of the School of Chinese Medicine at HKBU, demonstrated the in vivo therapeutic efficacy of a compound called F-SLOH in reducing the abnormal aggregation of Aβ, the hyperphosphorylation of tau proteins and neuroinflammation in the nerves cells in the brain, thereby improving the learning and memory functions of mice with AD. F-SLOH is a multi-functional cyanine probe synthesised by a team led by Professor Ricky Wong Man-shing for the detection of biological materials such as proteins and peptides. Its features include real-time visualisation of Aβ aggregation in brains, excellent permeability across the blood-brain barrier and low bio-toxicity. Previous studies showed that F-SLOH could inhibit the abnormal aggregation of Aβ species and provide neuroprotection against neurotoxicity induced by the abnormal aggregation of Aβ in vitro at the cellular level. F-SLOH improves pathological features in AD mice To determine the therapeutic efficacy of F-SLOH for AD, the researchers injected or fed F-SLOH to a group of transgenic AD mice. Histopathology and biochemical analyses showed that in mice treated with F-SLOH, Aβ oligomers (one of the Aβ species) and Aβ plaque deposits (the clumps of Aβ) were dramatically reduced in their hippocampus and their brains when compared with the AD mice in the control group who had not been fed F-SLOH. The researchers also found that F-SLOH can reduce the levels of an amyloid precursor protein that generates Aβ and tau protein hyperphosphorylation. In an immunoblot analysis of the transgenic AD mice brian, the F-SLOH treatment group showed a significant reduction in the levels of the amyloid precursor protein and its metabolites compared to the control group. In other experiments on the transgenic AD mice after F-SLOH treatment, the researchers separated the soluble and insoluble tau proteins in their brain tissue samples. The results showed that F-SLOH treatment significantly reduced the levels of insoluble tau protein in the brains of AD mice, which forms neurofibrillary tangles, one of the pathological features of AD. F-SLOH improves memory and cognitive functions in AD mice Aggregation of Aβ is closely related to the dysfunction of the links between nerve cells and memory decline. The researchers conducted two experiments to test the memory functions of AD mice. In the first experiment, mice were trained to swim in a water maze, reach a platform and remember its position. After the platform was removed, researchers observed whether the mice were able to recall and approach the original position of the platform. Compared to the control group, transgenic AD mice treated with F-SLOH spent more time swimming around the platform’s original position, showing that they can better memorise the platform’s location. In the second experiment, mice were placed in a chamber and exposed to an audio tone followed by an instant small electric shock to their feet from the floor of the chamber. On the following day, they were put back in the chamber but without any electric shock. When the mice were exposed to the same audio tone, they “froze” their body movements due to the fear of an electric shock. The transgenic AD mice treated with F-SLOH exhibited a longer freezing time than that of the control group. The results of the two experiments showed that AD mice treated with F-SLOH have better memories compared to the control group, suggesting that F-SLOH improved AD mice’s memory and cognitive functions. F-SLOH shows early potential for treating AD The researchers also revealed that F-SLOH degraded the abnormal aggregation of Aβ and reduced the levels of tau protein hyperphosphorylation, the amyloid precursor protein and its metabolites through the activation of the transcription factor EB. Transcription factor EB is the main regulator of the autophagy-lysosomal pathway, a major mechanism for degrading ageing intracellular macromolecular proteins, including the intracellular metabolites such as Aβ aggregates. Professor Li Min said: “AD patients lose their self-management abilities and require long-term care as the disease progresses. As the population is ageing in Hong Kong, the prevalence of AD is likely to increase. There is an urgent need to develop new drugs that can treat or slow down the progression of AD. The current study suggests that the compound F-SLOH has promising theragnostic potential for treating AD at an early stage.” Professor Ricky Wong Man-shing said: “The study provides the first in vivo evidence that F-SLOH is an effective agent that can target and treat multiple neurodegenerative changes in an AD mouse model. The research findings can drive advancements in AD diagnosis and treatment in humans.” Contact Details Communication and Public Relations Office at HKBU Christina Wu christinawu@hkbu.edu.hk

August 25, 2022 10:52 PM Eastern Daylight Time

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Tips on Navigating the Back-to-School Season

YourUpdateTV

A new school year brings the return of many emotions – excitement, happiness, and of course, a little stress. Siri Daly is partnering with Juicy Juice and recently participated in a nationwide satellite media tour to share her tips for conquering the organized chaos of back-to-school mornings. A video accompanying this announcement is available at: https://youtu.be/SeVtdSpQXLk With the school year just kicking-off, it’s inevitable for parents to be running around the house in the morning, scrambling to get the kids ready for school and out the door. Siri’s advice? Plan, plan, plan. Planning out outfits, schedules, and of course, lunches, helps to create a sense of calm in the morning. When it comes to packing those lunches, Siri suggests switching things up and asking the kids what they want to eat. If they ask for something specific, they’re more likely to eat it once at school – even if it’s leftovers from the night before! To help parents with lunches, Siri has created lunchbox ideas to add into the monthly rotation that are budget-friendly, well-balanced, and delicious enough that kids look forward to eating them each day. The lunchbox ideas call for simple staples and Juicy Juice 100% juice – an easy choice for mom and kids with a variety of flavors, no added sugar, no high fructose corn syrup and no artificial sweeteners. Here’s a taste of Siri’s kid-friendly lunches that can be prepped the night before to move through mornings with ease: PB&J Roll-ups+ Pretzels + Grapes + Juicy Juice 100% Juice, Fruit Punch Cheesy Egg Bites + Cherry Tomatoes + Tortilla Chips + Juicy Juice 100% Juice, Grape Cheese & Salami Kabob + Crackers + Cucumbers + Yogurt + Juicy Juice 100% Juice, Berry Juicy Juice is also giving parents the chance to win money for back-to-school supplies and groceries to make Siri’s lunchbox ideas. Each week for four weeks, one grand prize winner will win a $1,000 gift card and 10 others will win a $100 gift card. Juicy Juice will share a weekly post on Facebook, Instagram and Twitter asking followers to answer a question about their back-to-school moments. To enter, parents must follow @JuicyJuiceUSA, either post a photo or comment on Juice Juice’s weekly post in response to the prompt and include the following hashtags: #SIRIouslyRealBTS and #Sweepstakes. Parents can go to JuicyJuice.com/backtoschool to download and print the lunchbox calendar and learn more about the SIRIously Real Back-to-School Sweepstakes. About Siri Daly: Siri Daly is quickly leaving her mark on the entertainment-lifestyle landscape. She is the founder of Siriously Delicious, a popular food blog that chronicles real-life cooking and a former Food Contributor on the TODAY show where she still regularly appears as a guest chef for cooking segments. In addition to Siri’s primary Instagram, Siriously Delicious, she also has a comedic Instagram account, Real Moms Wear Grey where she shares a personal take on being a mom. Siri’s first cookbook, Siriously Delicious: 100 Nutritious (and Not So Nutritious) Recipes for the Real Home Cook was published by Time, Inc. books in 2018. Siri, along with her husband, Carson Daly and their four children live in the greater New York area. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

August 25, 2022 02:04 PM Eastern Daylight Time

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