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Pennsylvania Video Gaming Association (PaVGA) Advocates for Transition of Skill Games to Regulated Video Gaming Terminals (VGTs)

Pennsylvania Video Gaming Association (PaVGA)

The Pennsylvania Video Gaming Association (PaVGA), the statewide trade association representing manufacturers, distributors and operators of video gaming terminals, continues to support legislation to ensure that skill games are subject to the same regulatory requirements as gambling devices. Currently, skill games are not regulated by any state agency and are not subject to gaming taxes on net revenues as are slot machines, video gaming terminals (VGTs) and iGaming platforms. “Regulation would provide much-needed revenue to small businesses like bars, restaurants and veterans’ clubs, which would benefit from VGTs in those locations. The anticipated revenue from VGTs versus skill games is substantial,” stated PaVGA Executive Director Denise Calabrese. The operation of these games in bars, clubs and restaurants will provide a viable, sustainable revenue stream for struggling establishments who have been hit particularly hard by the COVID-19 pandemic, as well as a stable base of new revenues to the Commonwealth. “Because there has been no alternative sustainable option to gaming revenue for bars, veterans’ clubs, and restaurants throughout Pennsylvania, those venues have turned to the skill game industry for that revenue,” Calabrese explained. “The issue is that these devices, and the companies that own and manufacture them, are not regulated and there is no oversight of those companies, the individual’s who own those companies, or the devices. Pennsylvania’s bars, restaurants and veterans’ clubs, Pennsylvania Operators, and the thousands of consumers who choose this form of entertainment, deserve to know that their gaming options are being overseen by a government agency and that proper protocols are in place to protect them.” PaVGA believes that the Pennsylvania General Assembly needs to pass legislation with urgency to resolve this issue and ensure that any gaming devices operated in the Commonwealth are subject to the full oversight of the Pennsylvania Gaming Control Board (PGCB). During a Senate Community, Economic and Recreational Development Committee hearing on June 7, a Pennsylvania Senator stated there could be as many as 55,000 unregulated skill games currently in operation in Pennsylvania. While opponents to skill game regulation warn of detrimental impacts to the Pennsylvania Lottery and casinos, both continue to realize record high revenues. Furthermore, the same operator-based model PaVGA is advocating for in Pennsylvania has been successfully implemented in Illinois with negligible impact on the revenues of the lottery or casinos. “All we want to do is bring these unregulated games under the purview of the Pennsylvania Gaming Control Board to ensure that adequate protections are in place for consumers, establishments and operators,” Calabrese said. “This is more about applying equal standards to skill and gambling operations in the Commonwealth than it is VGT expansion. We have a statutory and regulatory structure already in place in the Commonwealth that provides for the safe, fair and equitable operation of VGTs. Skill games should be brought under that construct and be treated just like current gambling devices.” Contact Details Michelle Keyser Director of Communications +1 717-724-9166 communications@pavga.org

June 11, 2021 11:00 AM Eastern Daylight Time

Phantom Fireworks Urges Shoppers to Buy Early Amid Possible Fireworks Shortage as America Celebrates Fourth of July with Lowest Pandemic Rates in over a Year

Phantom Fireworks

The US’s largest consumer based retail fireworks company urges customers to shop for fireworks supplies early - as the industry, like many other industries, faces supply chain issues with global shipment delays Phantom Fireworks stores and retailers across the nation are ready to support shoppers seeking fireworks to celebrate the season - with extended store hours, in person shopping opportunities and additional staff to help fireworks buyers select the best products for their needs Fourth of July, America’s holiday, promises to be especially celebratory this year, as the nation reaches a key milestone in its recovery from the pandemic Phantom Fireworks, the country’s top consumer fireworks retailer, is urging shoppers to purchase their fireworks early this season as supply chains face slower turn-around times due to lagging global shipments spanning numerous industries. Despite shipment timing concerns, Phantom Fireworks still anticipates ample supplies of fireworks products available for a successful, safe and celebratory season - particularly as the nation’s leaders have designated this year’s holiday as the unofficial return to normal following the pandemic year. “Like many other industries, the fireworks industry has also experienced delays due to shipment challenges facing the global market,” said Alan L. Zoldan, Phantom Executive Vice President. “The good news is that we prepared early in anticipation of high demand again this year, and are encouraging Phantom customers to do the same. We are always excited to be a big part of America’s favorite holiday - the Fourth of July, especially meaningful following the 2020 pandemic summer.” Last year’s personal fireworks sales surged to record rates industry wide, including at Phantom Fireworks. Many communities had public fireworks displays postponed and cancelled at the height of the pandemic, and sporting events, amusement parks and concerts all but disappeared. Phantom Fireworks adapted to the 2020 pandemic surge by offering a variety of purchase options online and pick-up and offering in-store pandemic-friendly hours. This year’s Independence Day holiday is showing similar momentum as national leaders, including President Biden, have declared the summer holiday as the beginning point for the nation to “mark our independence” from the virus. Because of the high demand, Phantom Fireworks has been preparing for the season with additional store openings, early shopping incentives and updated inventory, despite the emergence of supply chain challenges. Company leaders are confident that planning ahead, and early shopping will allow for the supply to hold and avoid shortages of products as the holiday approaches. “Unlike last summer, we’re hopeful that most families can celebrate this Fourth of July season together,” said Bruce J. Zoldan, Phantom President. “Phantom Fireworks stands ready to help Americans turn the page this year - to enjoy our nation’s favorite summer holiday in their individual communities safely with Phantom Fireworks products - and with a promising future for the year ahead.” To follow Phantom Fireworks on social media, visit us on Twitter ( www.twitter.com/Fireworks ), Instagram ( www.instagram.com/phantomfireworks ) and Facebook ( www.facebook.com/fireworks ). For additional information on open stores and information on this year’s shopping process, visit: www.fireworks.com About Phantom Fireworks Phantom Fireworks is the top consumer fireworks retailer in the country with retail stores in fifteen states and is also the major July 4th product supplier to several national retail chains in all states that permit the sale of consumer fireworks. Each state has different laws and guidelines that regulate both the industry as well as the new COVID-19 reopening regulations. Phantom has a comprehensive and easy-to-find listing of state protocols on their website: https://fireworks.com/education-and-safety/state-laws-and-regulations Contact Details Amelia Hoffman AHoffman@fireworks.com Company Website http://www.fireworks.com/

June 10, 2021 02:05 PM Eastern Daylight Time

Centre for Neuro Skills Sets June 24 as Grand Opening for New Austin, Texas Clinic

Centre for Neuro Skills

The Texas Brain Injury Alliance reports that 144,000 Texans sustain a traumatic brain injury each year - one every 4 minutes. The Texas Department of State Health Services reports that approximately 72,500 Texas residents have strokes each year that require hospitalization. Now, more help is on the way. Centre for Neuro Skills (CNS), a premier provider of treatment for traumatic and acquired brain injury, announced the grand opening date of its new clinic in Austin, Texas. The clinic will celebrate with an invitation-only open house on Thursday, June 24. Former CNS patients Justin Glick and Megan Guerra are guest speakers who will share their rehabilitation stories. The 17,000-square-foot facility is located at 14425 Falconhead Blvd., Building F, Suite 200, Austin. A virtual tour of the new facilities is available. To access the tour, please click here. The Austin clinic is CNS’ fourth location in Texas, joining Dallas, Fort Worth and Houston. CNS also treats patients at three facilities in California. All CNS clinics offer a continuum of care approach to therapeutic rehabilitation and disease management services for those recovering from acquired and traumatic brain injuries. “No two brain injuries are the same,” said CNS’ Chief Medical Officer, Dr. Matthew Ashley. “What sets CNS apart is our whole team focus on patients and their caregivers. This new clinic will allow us to provide localized quality care to brain injury patients in Austin and Central Texas, which will ensure better recovery. Our goal is to maximize independence and improve quality of life.” Patient Success Story – Justin Glick Former CNS patient Justin Glick and his wife Caroline relocated to Austin from Los Angeles in 2020. They have since had their first baby, Sienna. After sustaining a traumatic brain injury at work, Justin sought treatment at the CNS Los Angeles clinic. He made a remarkable turnaround in just 47 days. Justin had spent his career in a highly specialized profession – the collecting and selling of rare coins, jewelry and watches. He’s now a real estate agent with Coldwell Banker in Austin. According to Justin, “the Centre for Neuro Skills has an amazing team that helped me literally get back on my feet and back to work. Caroline and I moved to Austin last year and absolutely love it. And now, we have our friends from CNS as neighbors. Austin is fortunate to have such an outstanding resource for brain injury rehabilitation.” Rehabilitative Technology Technology and advanced care systems at the Austin Clinic include: The ZeroG® Gait and Balance System, which helps patients relearn to walk, sit, stand, balance and improve gait. The Bioness Integrated Therapy System, which addresses vision, safety and motor balance training; the system supports returning to work and driving. The Independent Living Scale tracking system, which monitors patient progress. Tablets to record/integrate patient data in real time for analysis. Patient web portal for 24/7 secure access. Dedicated physician space, including a medical exam room, secured medication room and a nursing suite. Dedicated area for behavior analysis, including a meditation/quiet room. Patient and staff kitchen; computer center and offices for case management and administration. COVID-19 Safety Staff, patients and visitors are required to wear a mask at all times when in the clinic and common areas of residential homes. Clinic and residential visitors will have their temperatures taken upon entry. CNS clinics, homes and facilities observe CDC guidelines. About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Center for Neuro Skills, visit: https://www.neuroskills.com/, Facebook, Twitter, LinkedIn, YouTube. For a video overview of CNS, visit: https://youtu.be/Jwqve9gWtEw Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership, clinical staff or patient guests at or before the Grand Opening, please contact Robin Carr at (415) 971-3991 or CNS@landispr.com. Contact Details Landis Communications Inc. Robin Carr +1 415-971-3991 CNS@landispr.com Company Website https://www.neuroskills.com/

June 10, 2021 10:42 AM Pacific Daylight Time

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World’s largest product discovery platform RangeMe opens UK retailers to over 750,000 products

RangeMe

The world’s largest product discovery and sourcing platform RangeMe has launched in the UK today. Buyers at British retailers will now be able to source over 750,000 products and connect with more than 200,000 suppliers to fill their shopping aisles and online stores with curated products meeting consumer demand. Buyers at high street chain LloydsPharmacy are currently partnering with RangeMe. RangeMe first launched in 2013 and is used today by over 12,000 retailers in the U.S., including Walmart, Ulta Beauty, Walgreens, and Albertsons. It has quickly established itself as the industry leader for retail product discovery and sourcing by becoming the world’s largest source of brands and products purchased by buyers in the US. RangeMe helps retailers and their buying teams scale product sourcing efforts with streamlined submissions, simplified discovery tools, and the industry standard digital sell sheet. RangeMe enables buyers to filter searches to find brands meeting exact sourcing needs, enables seamless connectivity and collaboration with suppliers and provides curated collections to help identify and understand category trends and emerging brands. “Consumers are looking for a variety of products from all over the world and sourcing them online. The British public is no different, yet high street retailers have struggled to offer these products in store or online principally because they don’t have sight of all that’s available in the market. RangeMe will change this for retailers bringing more choice to shopping aisles and a significant revenue opportunity,” said Nicky Jackson, CEO of RangeMe. “We will pick up the heavy lifting for buyers and present the global product market opportunity in one screen”. LloydsPharmacy which caters to the medical, lifestyle and well-being needs of millions of people in the UK is an early adopter of the RangeMe platform. “We pride ourselves on offering the widest range of products that meet the highest standards for consumers. RangeMe is already helping us to identify a wider spread of products for our customers. Equally importantly, we will quickly scale our buying operations through the platform and reduce the time to get more products on our shelves” added John Acland, Head of Category Management and eCommerce at McKesson UK, parent company to LloydsPharmacy. RangeMe also invites British suppliers to join the platform for a front-row audience of the biggest high street retailers. It is a single place to represent their brand and products to a network of thousands of retail buyers. RangeMe helps suppliers grow their retail relationships with a platform that gives them the tools and insights to manage their products, market their brand, and build awareness. RangeMe is the global online platform where retailers and suppliers can discover, connect, and grow their business. Suppliers can showcase their range, bring new products to market, increase brand visibility, and grow sales, while buyers use RangeMe to discover new products, search trends, and communicate directly with brands. “Our mission has always been to empower retailers and suppliers to be productive and successful. The world has become a smaller place but it remains distant for forging strong cross border buyer and seller relationships. RangeMe will bridge this gap for buyers and sellers around the world and ensure extraordinary products hit store shelves, faster than ever before” added Nicky Jackson. About RangeMe RangeMe, an ECRM company, is the leading online platform that streamlines new product discovery between suppliers and retailers. The platform empowers retail buyers to efficiently discover innovative and emerging products, while streamlining the inbound product submission process. For product suppliers, RangeMe enables them to grow their retail relationships with a platform that gives them the tools to manage their products, market their brand, and build awareness. Now integrated into the ECRM product offering, RangeMe adds increased breadth and depth to the industry's most complete sourcing solution for top retailers and product suppliers. Contact Details RangeMe Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://www.rangeme.com/

June 09, 2021 04:00 AM Eastern Daylight Time

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Graton Resort & Casino Awarded Coveted AAA Four Diamond Rating

Federated Indians of Graton Rancheria

ROHNERT PARK, Calif. (June 8, 2021) – Graton Resort & Casino, a 65-acre resort with 200 upscale hotel rooms and suites, has joined the ranks of elite hotels across the country, earning a Four Diamond rating from AAA for its superior quality and service. Only 6.3 percent of the 27,000 hotels AAA evaluates annually are awarded the Four Diamond. “The Four Diamond honor is an outstanding achievement for Graton Resort & Casino and reflects our consistent mission to provide the highest quality guest experience. Our dedicated team goes above and beyond every day to make sure that our property is the best of the best,” said Greg Sarris, tribal chairman for Federated Indians of Graton Rancheria. “With California fully reopening on June 15, we look forward to welcoming all our guests back to experience our Four Diamond quality standard - and to have some fun at the same time!” Graton’s luxurious hotel rooms include: One king or two double beds, 515 square feet, designed with modern and contemporary décor. An exceptional degree of sleeping comfort, including 320-thread-count Egyptian cotton sheets, plush down duvets and hypoallergenic pillows. A 55-inch flat-panel television. Premium furniture and granite countertops that incorporate sleek design. Seating for three guests, including an ergonomic desk chair. A large writing station with multiple USB outlets. A central air conditioning system with digital thermostat. Bathrooms that feature a large vanity area with double sinks and multiple shelves for storage; and an enhanced large underlit mirror with makeup mirror. Premium heavyweight cotton towels. Enclosed water closet. Resort amenities include: The Spa & Salon, with 10,000 sq. ft. of high-quality treatments and services. A 1,200 square feet fitness facility with state-of-the-art cardiovascular and strength-training equipment. An expanded pool area (148,000-gallon swimming pool) with a bar, pool-side dining, spacious cabanas, and comfortable lounge chairs. A full gaming experience, with 3,000 slot and video poker machines, more than 130 table games and live poker. 24/7 concierge/room service for hotel guests. Guests have a complete range of dining options: 630 Park Steakhouse (fine-dining steak and seafood, with an extensive wine list). Tony’s of North Beach and Tony’s Slice House (Italian fare with pastas, pizzas, antipasti, and salads all prepared from Tony’s famous recipes. Tony’s was recently awarded “Best Pizzeria in America” by Forbes). Daily Grill (classic, fresh American fare). Boathouse Asian Eatery (innovative Asian cuisine). Marketplace, serving everything from burritos to burgers to noodle soups and specialty coffee drinks. For more information on Graton Resort & Casino or to book your stay, visit www.gratonresortcasino.com. ### MEDIA, PLEASE NOTE: To request further information and interviews or for additional images, please contact Brianne Miller at Graton@landispr.com or (650) 575-7727. About Graton Resort & Casino Located in Sonoma County, Graton Resort & Casino has a commanding presence among the rolling hills of Northern California's wine country. Owned and operated by the Federated Indians of Graton Rancheria, Graton Resort & Casino features table games, the latest slot machines, upscale and casual dining, plus entertainment options for visitors and locals alike. For more information, please visit www.gratonresortcasino.com. About the Federated Indians of Graton Rancheria Graton Rancheria is a federally recognized Indian tribe comprised of Coast Miwok and Southern Pomo Indians. Legislation restoring federal recognition to the Federated Indians of Graton Rancheria was signed into law in December 2000. Tribal lands are located in Rohnert Park, Sonoma County, CA. For more information, visit www.gratonrancheria.com. Contact Details Brianne Miller +1 650-575-7727 graton@landispr.com Company Website https://www.gratonresortcasino.com/

June 08, 2021 10:19 AM Pacific Daylight Time

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NextFerm Technologies Announces Successful Pilot for Industrial-Scale Production of ProteVin™, its Proprietary Vegan Protein

NextFerm Technologies Ltd.

NextFerm Technologies (TASE:NXFR), a Food-tech company developing ProteVin™, a vegan, non-GMO, yeast-based protein alternative, announced that it has successfully completed an industrial production pilot for ProteVin™. The successful pilot is the first of three milestones towards commercial production and launch of ProteVin™, planned in 2022. The two additional milestones are first, generating initial demand from the market and engagement with a first customer by the end of 2021; and second, entering into a production agreement with a subcontractor. As part of the pilot, which was conducted at production facilities in the US, the industrial production of the protein was examined while preserving the same characteristics that were achieved in the laboratory scale. Analysis of the results by independent laboratories, an internal team taste testers and a potential customer, showed that ProteVin™ successfully achieved all the pilot's objectives. Boaz Noy, Chief Executive Officer of NextFerm, said, “The successful industrial pilot of ProteVin™, marks an important achievement that brings us significantly closer to the planned commercial production and launch of ProteVin™ in 2022. The fast-growing alternative protein market is estimated at $13 billion, with an annual growth rate of 10%. The strong need for innovation by leading players in the food industry is for the protein itself, the raw material that is the foundation for all animal-derived food alternatives. The successful pilot reflects the outstanding value proposition of ProteVin™ as an alternative to animal-derived protein, with neutral flavor, the most important parameter for food manufacturers. This makes it accessible to a wide array of products such as milk and dairy substitutes, meat substitutes and additional categories such as infant nutrition, adult nutrition, and sports nutrition. Furthermore, for the first time, we bring the market a vegan protein with nutritional value that is higher than other plant-based proteins and that is comparable to animal-derived proteins. The nutritional advantage of ProteVin™ over other sources of plant-based proteins can be seen in its amino acid profile, which provides more essential amino acids (EAA) and more branched-chain amino acids (BCAA) and has better digestibility.” Mr. Noy Concluded, “We have recently begun sending commercial samples of ProteVin™ to potential customers worldwide. On the production side, we are in discussions with several potential subcontractors, in order to launch the product in 2022, as planned, and look forward to update our investors on our progress.” 1 st Target - Meeting the parameters determined that define the product: In tests performed by an independent laboratory, ProteVin™ met all parameters defined, including concentration of the protein, composition of amino acids, digestibility, light color, a product free of contaminants and allergens, and its compliance with food regulations and other quality parameters. 2 nd Target - Compliance with taste, flavor and odor requirements: ProteVin™ achieved neutral taste, flavor and odor requirements, without typical aftertaste and odor of various types of plant-based proteins. 3 rd Target - ability to supply samples of ProteVin™ for customers' approval: As part of the pilot, NextFerm produced a quantity of the protein sufficient to supply samples in the amount required for approval by potential customers. Customer testing includes integrating the protein in the prototype of their products, which is an essential step towards a commercial agreement with a customer. To the best of the company's knowledge, other than ProteVin™, there is currently no other protein alternative on the market with the same nutritional value and amino acid composition as animal-derived protein, and which has a neutral taste and flavor, with no aftertaste. In terms of regulation, ProteVin™ can be marketed in the US, Europe and other countries. About NextFerm Technologies NextFerm Technologies, traded on the Tel Aviv Stock Exchange (TASE:NXFR) is a food-tech company engaged in the research, development, manufacturing and marketing of innovative, functional and vegan yeast-derived, non-GMO protein alternatives for various applications in the food and food supplement markets and the growing market for animal-derived protein alternatives. NextFerm's flagship product is ProteVin™, a vegan yeast-derived protein alternative with nutritional value that is similar to animal-derived protein and a neutral flavor with no aftertastes that are typical of plant-based protein. ProteVin™ is designed for a variety of categories in the alternative protein market, which is estimated at $13 billion, with an annual growth rate of 10%, including the alternative meat market, milk alternatives and powder formulas for the infant nutrition market, for the wellbeing market and the market for athletes. NextFerm is gearing up for commercialization of the product in the US in 2022. Another product currently being sold is Astaferm®, an innovative astaxanthin-based antioxidant derived from yeast that has been sold in the US since the end of 2020 through well-established and leading brands in the food supplement market in the US. The company has additional products which have been licensed to Lallemand, a global giant focused on yeast. For more information, visit the NextFerm website at: www.nextferm.com Legal Notice Regarding Forward-Looking Statements This announcement also includes forecasts, projections, assessments, estimates and other information which refer to future events and matters, the realization of which is uncertain and not exclusively under the Company’s control (forward-looking information). The main facts and data used to support this information are facts and data regarding the current position of the Company and its businesses (including the scope of sales and levels of profitability, manpower, commercial engagements and more), facts and data regarding the current global position of the Company’s operating segments (including industry-specific financial developments, environmental regulatory developments, the competitive environment, technological developments, the reinsurance market and more), and macro-economic facts and data (including the economic situation both in Israel and around the world, yields in the capital markets, social and state developments and more), all as known by the Company when publishing this announcement. The forward-looking information included above in this announcement is significantly based upon, in addition to the existing information held by the Company, on the Company’s current assessments and expectations of future developments vis-a-vis each one of the aforementioned parameters, and the interconnectedness of each one of these developments. The Company has no certainty that its forecasts and assessments will indeed eventuate, and the Company’s operating results may be materially different than the results assessed or implicit based on that set forth above, inter alia, as a result of a change in any of the aforementioned factors. Contact Details NextFerm Technologies Ltd. Yossi Ohana - Chief Financial Officer +972 54-771-5893 yossio@nextferm.com Investor and Media Contact Meirav Gomeh-Bauer +972544764979 meirav@bauerg.com Company Website https://www.nextferm.com/

June 08, 2021 11:30 AM Eastern Daylight Time

How Split Annuity Strategies Work by Jennifer Lang Financial Services

Jennifer Lang Financial Services, LLC

Contact Details Jennifer Lang Financial Services, LLC. Jennifer Lang +1 877-487-8926 mail@jenniferlangfinancialservices.com Company Website https://www.jenniferlangfinancialservices.com

June 08, 2021 10:05 AM Eastern Daylight Time

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SCIENTISTS WORLDWIDE PLEDGE THEIR TRUST IN SCIENCE IN CELEBRATION OF THE INTERNATIONAL DAY OF LIGHT

International Day of Light Steering Committee

The UNESCO International Day of Light on May 16 th celebrated the worldwide campaign promoting the importance of science and the scientific process for society and sustainable development. The Trust Science pledge saw supporters of science worldwide join together to affirm their appreciation for science. Notable signatories include Nobel and Breakthrough laureates, UNESCO prizewinners, CEOs, representatives from scientific societies and academies, individual scientists and students from nearly 100 countries. “After a year in which we have seen science lead the global response to the coronavirus pandemic, we thought it was essential to highlight the importance of trusting its methods in guiding decisions,” said Steering Committee Chair John Dudley. “The pledge focuses particularly on science’s role in improving quality of life, a sentiment that clearly resonates around the world.” The International Day of Light recognizes the value of light science and technology and its role in providing clean energy, clean water, high-speed connectivity and medical treatments. The day was celebrated with events and hands-on activities in more than 55 countries. The International Day of Light also highlighted the achievements of a number of Champions of Science, individuals from all fields whose work is changing the world. “As a scientist, seeing this kind of support for the scientific process is inspiring,” said Neysha Lobo-Ploch, FBH Berlin, UVphotonics NT GmbH, Germany and LightDay 2021 champion. “I’m honored to have my work acknowledged in this way.” After its initial launch with the International Day of Light, the #TrustScience campaign will continue throughout 2021, and scientists worldwide will be organising targeted actions throughout the year. Dudley explains, “A central aim of this initiative has been to remind members of the scientific community that we share a responsibility to ensure that the public has confidence in science and its outcomes. It is up to us to explain how science works and why it can be trusted.” The Trust Science campaign is organized by the IEEE Photonics Society, SPIE, the international society for optics and photonics, and The Optical Society (OSA), together with the International Day of Light Steering Committee. To sign the pledge and to learn more, please go to https://www.trust-science.org Contacts For questions about how you can engage with the campaign, please contact: info@trust-science.org For media inquiries, please contact: pr@trust-science.org Social media: please share using #TrustScience and #LightDay2021 Social media links: Facebook; Instagram; Twitter About the International Day of Light The International Day of Light (LightDay)is a worldwide initiative that provides an annual focal point for the continued appreciation of light and the role it plays in science, culture and art, education and sustainable development, and in fields as diverse as medicine, communications and energy. The International Day of Light is administered from the International Basic Science Programme (IBSP) of UNESCO by a Steering Committee that includes representatives from a broad range of international partners: the American Institute of Physics (AIP), the American Physical Society (APS), Bosca, the China International Optoelectronic Exhibition (CIOE), Chinese Optical Society (COS), the European Centres for Outreach in Photonics (ECOP), the European Photonics Industry Consortium (EPIC), the European Physical Society (EPS), the Illuminating Engineering Society (IES), the International Centre for Theoretical Physics (ICTP), the IEEE Photonics Society (IPS), the International Commission on Illumination (CIE), lightsources.org - the international network of accelerator based light sources, Light: Science and Applications, The Optical Society (OSA), Tampere University, SPIE, the International Society for Optics and Photonics, SESAME, Signify, Tampere University, Thorlabs, Transitions, the Université de Franche-Comté and Velux. For information about the International Day of Light, please visit www.lightday.org Contacts for IDL: John Dudley and Joseph Niemela Bethany Downer 2021 Steering Committee Chairs 2021 Communications Coordinator Email: contact@lightday.org Email: contact@lightday.org Media Contact for Trust Science: pr@trust-science.org About IEEE Photonics Society The IEEE Photonics Society is the professional home for a global network of scientists, engineers and allied professionals who advance laser, optoelectronics, and photonics technology. As a technical society representing the IEEE, it is a vital part of the world’s largest technical professional organization of more than 400,000 members dedicated to advancing technology for the benefit of humanity. Through its highly cited publications, conferences, technology standards, educational activities, and humanitarian initiatives, the IEEE Photonics Society provides its members in more than 160 countries the opportunity to grow professionally and stay on the forefront of transformational breakthroughs in photonics. PhotonicsSociety.org About SPIE SPIE, the international society for optics and photonics, was founded in 1955 to advance light-based technologies. Serving more than 255,000 constituents from 183 countries, the not-for-profit society advances emerging technologies through interdisciplinary information exchange, continuing education, publications, patent precedent, and career and professional growth. SPIE annually organizes and sponsors approximately 25 major technical forums, exhibitions, and education programs in North America, Europe, Asia, and the South Pacific. In 2020, SPIE provided more than $5 million in support of education and outreach programs. www.spie.org About The Optical Society Founded in 1916, The Optical Society (OSA) is the leading professional organization for scientists, engineers, students and business leaders in light science and technology. The society serves over 432,000 customers and 22,000 members from more than 100 countries who fuel discoveries, shape real-life applications and accelerate achievements in the field. OSA provides quality research, inspired interactions and dedicated resources for its extensive global network of optics and photonics experts through world-renowned publications. For more information, visit osa.org. Contact Details pr@trust-science.org +1 703-907-0010 pr@trust-science.org Company Website https://www.trust-science.org

June 08, 2021 09:58 AM Eastern Daylight Time

New Study from ZOE Shows Significant Inflammatory Responses After Meals

ZOE

Scientists at health science company ZOE and King’s College London today published novel research in the peer-reviewed American Journal of Clinical Nutrition. The study shows that acute and prolonged food-induced inflammation can increase the predicted risk of developing cardiometabolic diseases like cardiovascular disease. As the largest in-depth global study to look at postprandial inflammation, researchers found that inflammation, triggered by food, varies widely between individuals. Moreover, for the first time in a study of this scale, researchers were also able to identify the relative influence of blood sugar and blood fat levels on inflammation, demonstrating a stronger link with blood fat responses than blood sugar. These findings highlight the potential for personalized strategies to reduce chronic inflammation in preventative health. The facts on inflammation and food: Inflammation is a normal biological process caused by the immune system responding to injury. However, sustained long-term (chronic) inflammation is linked to many health conditions, including type 2 diabetes and heart disease Researchers measured levels of fat, sugar and inflammatory markers in the blood of 1,000 PREDICT participants who had eaten set meals at specific times, making this by far the largest study of the impact of food on postprandial inflammation in the world Most people experienced some level of inflammation after eating but the amount varied widely between people, depending on their unique biology. For the first time, this study shows that changes in the levels of fat in the bloodstream after eating have a greater influence on inflammation than blood sugar levels. This shows that only concentrating on a single measure like blood sugar or blood fat is not the right strategy for overall dietary advice There are several strategies that people can use to reduce food-induced inflammation Understanding your personal nutritional responses after eating can enable you to make food choices that will help reduce inflammation and better support your health Measuring inflammation after eating Led by Dr. Sarah Berry and her team at King’s College London and ZOE, in collaboration with Massachusetts General Hospital and additional researchers in the US, UK, Italy, Spain and Sweden, the PREDICT study invited 1,002 healthy adults taking part in the PREDICT research program to come into the team’s research clinic for a day. They were all given two standardized meals to eat, each containing precise amounts of fat, carbohydrate, fiber and protein: breakfast (a muffin and a milkshake) and lunch 4 hours later (a muffin). The researchers took blood samples from the participants before the breakfast meal and at nine points throughout the day. These were then analyzed to measure the levels of blood fat and sugar at the different timepoints, along with levels of two markers of inflammation, interleukin 6 (IL-6) and Glycoprotein acetylation (GlycA). While IL-6 has conventionally been used as a measure of inflammation, GlycA has recently emerged as a more robust marker. Higher levels of GlycA are also associated with a number of health conditions, including fatty liver, type 2 diabetes, heart disease and some cancers. Dr Sarah Berry from King’s College London, who led the study, explains, “Several small studies have previously tried to look at the relationship between food and inflammation, but the results have been inconsistent due in part to the challenges in measuring levels of inflammation after eating from blood samples. Thanks to recent advances in metabolic science, we were able to take advantage of a novel marker, GlycA, to gain new detailed insights into the connection between food and inflammation.” Additionally, the researchers also gathered detailed data on the participants’ health, including information about their typical diet, a stool sample for microbiome analysis, and a body fat scan. Individual inflammation responses after eating vary widely The researchers found that the levels of inflammation after eating varied widely between participants, including identical twins, even though everyone had exactly the same meals at the same intervals. For the first time in a study of this scale, the researchers were able to separate out the influence of blood sugar and blood fat levels on inflammation. While both unhealthy fat and sugar responses were associated with higher levels of inflammation after eating, blood fat was a stronger predictor of food-induced inflammation than blood sugar. People with more body fat and greater body mass index (BMI) were more likely to have higher levels of inflammation after eating, supporting current evidence that management of obesity will reduce chronic inflammatory burden. Levels of inflammation also tended to be higher in males than females, and in older participants than younger ones. How to control food-related inflammation Berry explains, “Experiencing inflammation after eating is a normal biological response, but prolonged, sustained periods of inflammation have been linked to health conditions such as type 2 diabetes and heart disease. If you have less healthy responses to fat or sugar, then it’s easier to overload your system after eating, leading to increased inflammation.” Based on these findings, Dr Berry recommends several strategies to help reduce the impact of inflammation after eating: Control unhealthy blood fat responses by choosing whole foods that are higher in fiber and lean protein, increasing your intake of healthy omega-3 fats from sources like fish, nuts and seeds, and reducing your overall body fat Control unhealthy blood sugar responses by choosing foods containing complex carbohydrates and fiber, such as whole grains, fruit and vegetables, and limiting sugary processed foods and sodas Reduce inflammation after eating by choosing foods that are high in ‘anti-inflammatory’ bioactive molecules such as polyphenols, found in colorful fruits and vegetables and other plant-based foods Understand your biology and choose foods that are less likely to cause unhealthy blood fat or sugar responses after eating Tim Spector, Professor of Genetic Epidemiology at King’s College London and scientific co-founder of ZOE, adds, “Previous results from our PREDICT study showed that the combination of microbes living in our guts, known as the gut microbiome, is closely linked to how we respond to food, particularly fat. We have also found that microbiome composition is strongly associated with GlycA levels, opening the door to reducing food-related inflammation and improving health by manipulating the microbiome.” To help bring this cutting-edge science to everyone, ZOE now offers an at-home test that measures blood fat, sugar and inflammation levels after eating, along with in-depth microbiome analysis, and provides personalized advice on the best foods to eat to support overall health. Professor Spector concludes, “Our PREDICT research program is the largest study of its kind in the world, and results like this mark important steps forward in unpacking the complex connection between diet, inflammation and health. Our mission at ZOE is to enable anyone to understand their own unique biology and make food choices that optimize their health through the latest advances in nutritional science.” Find out more about the ZOE at-home test and nutrition program at joinzoe.com. Notes and resources: Link to proof Read more about the PREDICT research program: joinzoe.com/post/what-is-predict Read more about how ZOE’s research uses standardized muffins to measure metabolic responses: joinzoe.com/post/muffin-metabolism-predict Read ZOE’s White Paper on inflammation, diet and health: joinzoe.com/whitepapers/dietary-inflammation Learn more about the science behind ZOE: joinzoe.com/whitepapers/overview ZOE’s previous research on the link between the gut microbiome and responses to food: joinzoe.com/post/nature-microbiome-discoveries Find out more about the ZOE at-home test and nutrition program at joinzoe.com ZOE is a healthcare science company helping people understand their body’s responses to food. By using machine learning combined with large scale human studies, ZOE is decoding the impact of nutrition on health. ZOE leads the PREDICT Studies and the COVID Symptom Study, which are the world’s largest community-powered research programs of their kind in nutrition and COVID-19 respectively. Located in London and Boston, ZOE was founded by Professor Tim Spector of King’s College London, data science leader Jonathan Wolf and entrepreneur George Hadjigeorgiou. ZOE was named one of the Deloitte Fast 50 Rising Stars in 2019 for the company’s contribution to science enabled by technology and machine learning. For more information on ZOE’s mission and science, visit joinzoe.com. Contact Details ZOE Fiana Tulip +1 817-691-3031 fiana@joinzoe.com Company Website https://www.joinzoe.com

June 08, 2021 08:34 AM Eastern Daylight Time

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